Which position of the person and which positions of the electrodes on the shoulder create the best recorded and best reproducible muscle amplitude?
ID
Source
Brief title
Condition
- Neuromuscular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
CMAP-amplitude of the trapezoid muscle: amplitude itself and the difference
between repeated measurement.
Secondary outcome
not applicable
Background summary
Repetitive nerve stimulation (RNS) is an important diagnostic test for disease
of the neuromuscular junction like myasthenia gravis (MG). In MG proximal
muscles are more vulnerable to disease than distal ones, so RNS of a proximal
muscle is more sensitive to diagnose MG. RNS in a proximal muslce is tecnically
more difficult and only moderately reproducible. Because raisin gevidence is
mounting that RNS can and will be used as marker for disease severity, a
reproducible test has become more important.
Study objective
Which position of the person and which positions of the electrodes on the
shoulder create the best recorded and best reproducible muscle amplitude?
Study design
Persons are tested on two different days by the same protocol. Three
combinations of two electrodes (20x30mm) are attached to the shoulder. The
nerve is stimulated in the neck. The reactions of the muscle, measured between
the electrodes, are recorded simultaneously. The combination of electrodes with
the best reproducible result is determinde by statistical analysis.
Study burden and risks
thirty minutes, twice
The RNS can be uncomfortable and sometimes even be painful.
Albinusdreef 2
2333 ZA
NL
Albinusdreef 2
2333 ZA
NL
Listed location countries
Age
Inclusion criteria
at least 18 years old
able to give informed consent
Exclusion criteria
neuromuscular disorders of nerve and muscles
diseases predisposing to nerv or muscle disease, for example diabetes mellitus
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL19299.058.07 |