To determine the natural history and long term (10 years) outcome of CSR.
ID
Source
Brief title
Condition
- Retina, choroid and vitreous haemorrhages and vascular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
At presentation:
- Proportion of CSR patients with signs of DRPE
- Proportion of CSR patients with bilateral involvement
Long-term (10 year) follow-up:
- Visual acuity of CSR and fellow eye (ETDRS chart)
- Contrast sensitivity of CSR and fellow eye (Pelli Robson chart)
- Color vision of CSR and fellow eye (HRR)
- Standardised OCT, fundus, red free and autofluorescent photograph analysis of
both eyes
- Proportion of pure CSR patients that have evolved to DRPE
- Proportion of patients with initial signs of DRPE that has evolved to more
severe DRPE
Prognostic factors:
- Gender
- Age onset
- Use steroids
- Use anxiolytics
- Bilateral involvement at onset
- Number of clinically documented episodes
- Use laser
Concomitant diseases:
- Helicobacter pylori positive
- Adrenal steroids values (elevated / normal / decreased)
- Are there endocrinologic or cardiovascular disorders associated with earlier
CSR
- Stress questionnaire
Effect of laser treatment:
- Association of laser and longterm VA
- Localisation of laser burns
- Association of laser and evolution into DRPE
Secondary outcome
See primary parameters.
Background summary
Central serous retinopathy (CSR) is a (usually temporary, unitlateral) disorder
characterized by impaired fluid transport across the retinal pigment epithelium
in the central macula. The result is blurred and/or distorted vision. Many
questions about etiology, prevalence, eventual progression into a more chronic
form, and efficacy of treatment remain unresolved. Collecting basic data may
improve future prognosis and treatment.
Study objective
To determine the natural history and long term (10 years) outcome of CSR.
Study design
Case series / cohort study.
Study burden and risks
For this study, a single (voluntary extra control) visit is required.
Examination comprises routine ophthalmic, non-invasive, procedures. Blood
samples require a single venous puncture. Therefore, burden will be low and
risk is negligible.
Schiedamse Vest 180
3011 BH Rotterdam
Nederland
Schiedamse Vest 180
3011 BH Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
- Age >=18 years.
- Informed consent.
- FAG available from 1995 or 1996.
- Diagnosis CSR in 1995 or 1996.
Exclusion criteria
NA
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL16963.078.07 |