The present study aims to investigate genetic factors that contribute to the development of BE.
ID
Source
Brief title
Condition
- Gastrointestinal inflammatory conditions
- Gastrointestinal neoplasms malignant and unspecified
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
•Familial incidence of GERD, BE and EAC in first en second degree relatives of
patients with BE in the Netherlands.
Secondary outcome
•Gene-environment interactions on familial susceptibility to GERD and BE
•Incidence of EAC in family members of patients with GERD and BE.
•Reported polymorphisms in BE are predictive for developing BE in relatives of
patients with this disorder.
Background summary
In the last three decades, the incidence of esophageal adenocarcinoma (EAC) has
dramatically increased. Most cases of EAC arise in Barrett*s esophagus (BE).
There are several risk factors that predispose to BE, such as older age, male
gender and gastro-esophageal reflux disease (GERD). There is increasing
evidence that an underlying genetic susceptibility may contribute to the
development of GERD and BE. Several studies have reported a familial prevalence
of BE and EAC.
Study objective
The present study aims to investigate genetic factors that contribute to the
development of BE.
Study design
Cohort study in BE-patients and their relatives to investigate the incidence of
familial BE and the possible genetic factors contributing to BE and EAC.
Study burden and risks
BE-patients and their relatives will be asked to give a blood sample. The
family members will be offered a gastroscopy to detect the presence of BE. A
gastroscopy is considered to be a low risk intervention.
's Gravendijkwal 230
3015 CE Rotterdam
Nederland
's Gravendijkwal 230
3015 CE Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
Patients:
- Age >= 18 years
- Informed consent
- Participating in the CYBAR study ( histological confirmation of diagnosis of BE);Family members:
- Age >= 18 years
- Informed consent
Exclusion criteria
- Unable to fill out questionnaire
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL17484.078.07 |