Reserach to the observation of neurophysiologic pain mechanisms and the differences between healthy subjects and pain patients.
ID
Source
Brief title
Condition
- Spinal cord and nerve root disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Reported pain experience (0-100)
Amplitudes of the EP components measured at CZ-A1A2 (P90, N150, P200 and P300)
Amplitudes of the EP components measured at C4-FZ and C3-FZ (P50 and N90)
Secondary outcome
Cortical areas
data from diagnosis file of radicular pain patients
area of compression or irritation radix
nature of pain complaints
duration of pain complaints
medication
applied diagnosis techniques
treatment patients
Background summary
Chronic pain is an increasing problem for both healthcare and the social
security system as for medical science. Still a lot is unknown about the
neurophysiological pain mechanisms underlying chronification of pain.
Study objective
Reserach to the observation of neurophysiologic pain mechanisms and the
differences between healthy subjects and pain patients.
Study design
The stimulation location of the electrical stimulus (left forearm or left
middle fingertip) is the only difference between both experiments. In an
experiment the electrical stimulus will be modulated by two different methods;
by modulation the amplitude of a single pulse or modulation of the number of
pulses in a pulse train with fixed amplitude. In combination with the
electrical stimulus the subject will put his right hand up to the wrist in ice
water or water with the temperature of 32ºC (warm nor cold). Besides reported
pain experience, the brain activity after the electrical stimulus will be
measured by electroencephalography (EEG). A part of the subjects will be
measured twice.
Study burden and risks
The used methods are non invasive. The maximal duration of an experiment is 2.5
hour. The actual duration of the measurement will be 1 hour. During the rest of
the time the EEG electrodes and stimulation electrode will be fixed (45
minutes) and there will be breaks between the measurements (45 minutes). There
are no considerable physical or mental risks joined with this research.
postbus 50000
7500KA Enschede
Nederland
postbus 50000
7500KA Enschede
Nederland
Listed location countries
Age
Inclusion criteria
For both healthy and radicular pain patients
Right handed
age 18-65
Radicular pain patients
radicular pain syndrom diagnosed by the neurologist or clinical neurophysiologist
Exclusion criteria
Both healthy and radicular pain patients:
Psychotropic medication
healthy subjects:
pain complaints during the experiments
pain complaints for more than 1 week during previous 3 months
psychotropic medication
Radicular pain patients
other pain complaints;Radicular pain patients:
psychotropic medication
other pain complaints
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL17719.044.07 |