* Establish the relationship between plasma levels and the development of infectious complications. * Determine the genetic variants of the MBL-gene.
ID
Source
Brief title
Condition
- Hepatobiliary neoplasms malignant and unspecified
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Plasma concentration levels of MBL in trauma patients.
Secondary outcome
Development of infectious complications and death within the first 30 days
after trauma in relationship to baseline and follow-up plasma levels of MBL.
- ISS, age, gender, region of injury, mortality.
- pneumonia, ARDS, SIRS, MOF, sepsis, wound infection, wound dehiscence,
urinary tract infection, intra-abdominal abscess.
Background summary
The role of genetics in developing infectious complications is made clear by
recent studies. Genetic markers suspected are interleukins, tumor necrosis
factor, HSP (heat shock protein), and PAI-1 (plasminogen-activator-inhibitor
1). Most of these markers are already investigated in relation to complication
development in non-trauma patients.
A relatively risk factor for infectious complications is MBL (mannose-binding
lectin) deficiency. The role of MBL deficiency in developing the most common
infectious complications in trauma patients is still unclear.
Early detection of risk factors in trauma patients for developing one or more
complications is of great importance to give insight in the pathogenesis of
these disorders, leading to improved strategies for their prevention,
diagnosis, and treatment. Therefore, in this study the role of MBL in
complication development in trauma patients will be investigated.
Study objective
* Establish the relationship between plasma levels and the development of
infectious complications.
* Determine the genetic variants of the MBL-gene.
Study design
Prospective cohort study.
Study burden and risks
First blood samples are taken concomitant with blood sampling for laboratory
test as normal acute trauma care (shock room) procedure. Sampling at day 1
will be done simultaneously with standard laboratory tests as part of standard
posttrauma care. Therefore risks will be low and comparable to blood samples
taken under normal circumstances.
Meibergdreef 9
1105 AZ Amsterdam
Nederland
Meibergdreef 9
1105 AZ Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
Trauma patients admitted to the shock room of the emergency department of the Academic Medical Center, Amsterdam. These patients either meet the criteria of high energy trauma, or are otherwise suspected to have potentially life threatening injuries.
Exclusion criteria
Patients younger then 18 years old.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL17553.018.07 |