The aim of this study is to directly compare two last generation FPMPI pulse sequences (EPI and SSFP) in a group of patients with suspected CAD.
ID
Source
Brief title
Condition
- Coronary artery disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Comparison of image quality and artifacts, intra- and interobserver variability
and diagnostic accuracy.
Secondary outcome
NA
Background summary
Magnetic resonance First pass myocardial perfusion imaging (FPMPI) is an
established technique for the evaluation of myocardial perfusion. However,
current pulse sequences still have some limitations (triggering or motion
artifacts) and ongoing optimization of pulse sequences is required. This
project focuses on two last generation sequences, SSFP and EPI, both optimized
using parallel imaging.
EPI is faster, and theoretically has less motion artifacts, whereas SSFP has
higher signal-to-noise and potentially more reliable semi-quantitative
analysis.
Study objective
The aim of this study is to directly compare two last generation FPMPI pulse
sequences (EPI and SSFP) in a group of patients with suspected CAD.
Study design
Observational study in which EPI- and SSFP-FPMPI will be done within a period
of 2 weeks.
Study burden and risks
The burden is considered low: 1 extra visit for an MR examination of 20
minutes. Risks are negligible. During the study the vasodilating substance
adenosine will be infused during 3 minutes, which may lead to mild and short
lasting side effects that will be familiar from the first study. MRI is not
radiotoxic, and harmful effects of its repeated use or of the contrast agent
have not been reported.
Postbus 7057
1007 MB Amsterdam
Nederland
Postbus 7057
1007 MB Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
All patients aged 30-70, referred for diagnostic FPMPI to the CMR department at the VU Medical Centre are study candidates.
Exclusion criteria
Severe adenosine (heart block > 1st degree), or contrast (allergy) related side effects during initial study).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL18067.029.07 |