To identify risk factors that might contribute to the development of post-traumatic HHD in children in order to reduce the lag-time between onset and diagnosis for future patients. To investigate the level of functioning and the quality of life of…
ID
Source
Brief title
Condition
- Hypothalamus and pituitary gland disorders
- Central nervous system vascular disorders
- Developmental disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Type of pituitary dysfunction in relationship with TBI in children in the
Netherlands
Risk factors and mechanisms for HHD in children withTBI
Secondary outcome
Emotional and physical development and functioning in children after a TBI.
Quality of life
Background summary
See page 8 and further in protocol.
Study objective
To identify risk factors that might contribute to the development of
post-traumatic HHD in children in order to reduce the lag-time between onset
and diagnosis for future patients.
To investigate the level of functioning and the quality of life of children,
young adult and adolescents 8 years after a traumatic skull/ brain injury.
Study design
See page 13 of the protocol
Study burden and risks
Risk are low: one venapunction and one X ray left hand (bone-age).
Patients might benefit from this trial, because patients with TBI,
participating in this study, can be diagnosed in an earlier stage with possible
effects of this TBI, like endocrine dysfunction. This was described in adult
patients, but only in case reports in children.
It is important that children with TBI are followed up as a group, because it
is essential to describe the effects of this TBI on their development. This can
only be done in children who suffered from TBI. Often disorders post accident
are related to the accident itself, but not related to possible endocrine
disorders following the brain injury.
Dr. Molewaterplein 60
3015 GJ Rotterdam
Nederland
Dr. Molewaterplein 60
3015 GJ Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
traumatic brain injury; children < 18 years; Glasgow coma scale < 9.
Exclusion criteria
Not part of the IMPACT study 2000/2001
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL19529.078.07 |