Assessment of the microvascular architecture of the lip and nailfold by orthogonal polarisation spectrum imaging

In subjects with hypertension and diabetes the microvasculature plays an
important role in the pathogenesis of the technique. Although several
techniques are available for assessment of macrovascular structure and
function, few and inferior techniques are used foor assessing microvascular
structure. A new technique, orthogonal polarisation spectrum imaging is a
promising new method to perform microvascular structure measurements.

To assess the microvascular architecture in lip and nailfold of healthy
volunteers. To determine reproducibility of the OPS imaging technique for
assessment of microvascular architecture.

Observational in healthy volunteers.

Four measurements are performed in each lip quadrant (2 upper lip and 2 lower
lip quadrants). Thus a total of 16 measurements. Each subject is measured on 2
occasions. Nailfold microvascular architecture is determined before and after a
2-minute inflation of a finger cuff.

Very limited time burden. No relevant risk due to non-invasive character of the
measurements.