Objective: Evaluation of the supposed correlation between increased serum and urine NGAL levels (> 350 ng/ml) and significant increases in serum creatinine levels in adult ICU patients compared to preclinical levels
ID
Source
Brief title
Condition
- Renal disorders (excl nephropathies)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Main study parameters/endpoints: Urine and serum NGAL levels, serum creatinine,
urine sodium, chloride, osmolality and creatinine levels
Secondary outcome
nvt
Background summary
Rationale: Renal injury is a common problem in the critically ill patient. The
wide range of renal injury spreads from sub clinical minimal changes in
creatinine levels to complete failure resulting in kidney replacement therapy.
An ischemic or nefrotoxic event usually results in increased serum creatinine
levels several days later compared to preclinical/pre-admission creatinine
levels. Neutrophil Gelatinase-Associated Lipocalin (NGAL) seems to be an early
detector of ischemic tubular damage above the cut off point of 350 ng/ml.
However, evidence of correlation of increased creatinine levels, fractional
sodium and chloride excretion and NGAL levels in serum and urine in adult ICU
patients is limited. This warrants a study assessing this correlation in an
adult ICU population.
Study objective
Objective: Evaluation of the supposed correlation between increased serum and
urine NGAL levels (> 350 ng/ml) and significant increases in serum creatinine
levels in adult ICU patients compared to preclinical levels
Study design
Study design: Observational study.
Study burden and risks
nvt
PO BOX 2040
3000 CA Rotterdam
Nederland
PO BOX 2040
3000 CA Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
All consecutive patients admitted to the general ICU meeting the subgroup criteria with obtained informed or deferred consent would be included. Patients will be recruited from the Erasmus MC University Medical Center Rotterdam.
Exclusion criteria
Patients will be excluded if the treating physician judges that study participation is undesirable for medical, medical-ethical or other reasons. Patients with a history of chronic renal failure and preadmission chronic hemofiltration or Continuous Ambulatory Peritoneal Dialysis (CAPD).
Patients with urothelial malignancies will be excluded.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL17386.078.07 |