To investigate if the intraoperative biventricular pacing can improve the hemodynamic performance and decrease the need of mechanical and pharmacological support.
ID
Source
Brief title
Condition
- Heart failures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Changes in left ventricular pressures after biventricular pacing in comparison
with the patient*s own rhythm and right ventricular pacing.
Secondary outcome
Perioperative changes in hemodynamic performance and need for mechanical and
pharmacological support after biventricular pacing.
Background summary
Cardiac resynchronization Therapy (CRT) can acutely improve cardiac performance
as expressed by increased pulse pressure and LV dP/dt max. Moreover, cardiac
function improves at diminished energy costs. Implementing CRT during and after
cardiac surgery could improve hemodynamics and lessen the need for inotropic
medication.
Study objective
To investigate if the intraoperative biventricular pacing can improve the
hemodynamic performance and decrease the need of mechanical and pharmacological
support.
Study design
A prospective mono-center study.
Study burden and risks
There is no extra risk for the patients by insertion of a pacemaker lead or
measuring the hemodynamic data intra and postoperatively.
Michelangelolaan 2
5623 EJ Eindhoven
Nederland
Michelangelolaan 2
5623 EJ Eindhoven
Nederland
Listed location countries
Age
Inclusion criteria
• Age of 18 years or more.
• Patients scheduled for coronary artery bypass grafting surgery (CABG) and/or valve surgery.
• Left ventricular ejection fraction (EF) of 35% or less.
• Sinus rhythm with one of the following criteria:
1. QRS duration of > 130 ms and left bundle branch pattern
2. Pacemaker dependent patients with right ventricular paced rhythm and QRS width of > 180 ms, or
3. Evidence of left ventricular dyssynchrony with Tissue Doppler Imaging (TDI)
• Able to give informed consent.
Exclusion criteria
Myocardial infarction within the past 3 months
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL17161.060.07 |