To reduce postoperative blood loss by improving platelet function in autologous blood donation
ID
Source
Brief title
Condition
- Platelet disorders
- Cardiac therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
for part I, in vitro platelet function during period of cardio pulmonary bypass.
for part II, reduction of blood loss and quality of clotting
(Thromboelastogram and platelet function) after cardio pulmonary bypass.
Secondary outcome
quality and quantity of blood clotting and platelet function after 2 hours in
Intensive Care. Rethroacotomies for increased blood loss
Background summary
During heart surgery autologous blood donation is used to preserve platelet
function. Literature search shows no benefit of storage in either citrate or
heparin. Both preservation techniques reduce platelet function over time
irreversibly. For this study an alternative strategy is studied to improve
platelet preservation.
Study objective
To reduce postoperative blood loss by improving platelet function in autologous
blood donation
Study design
The study consists of two parts. In part one the best alternative preservation
strategy is choosen with in vitro tests. In part two of the study this strategy
is tested for clinical effects on blood loss and tranfusion need against a
control group wereby blood is donated in heparin.
Intervention
Comparison of autologous blood transfusion preserved in heparin (control group)
against an alternative strategy (blood preserved in bivalirudin).
Study burden and risks
There is no burden for the patietn. The study is carried out during the period
under anesthesia. There are no additional risks for the patients. Autologous
blood donation is a standard therapeutic procedure in our centre for cardiac
surgery.
Hanzeplein 1
9713 EZ
Nederland
Hanzeplein 1
9713 EZ
Nederland
Listed location countries
Age
Inclusion criteria
haemoglobin level of 8 mmol/L
Exclusion criteria
use of platelet inhibitors
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL19196.042.07 |