Obtaining a first impression of the potential effect of a combined lifestyle intervention (exercise and weight loss), executed in patients with osteoarthritis of the hip.
ID
Source
Brief title
Condition
- Joint disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Self-reported physical function as measured by the Western Ontario and McMaster
Universities Osteoarthritis Index (WOMAC) (Roorda et al., 2004).
Secondary outcome
Body weight; height, objective functional abilities measured with use of a
walking test of 20 meters, and the Timed Up and Go test (de Greef et al 2006);
Pain measured by the WOMAC physical function scale and the health related
Quality of Life measured by the SF-36 (Aaronson et al., 1998). The SQUASH
(Wendel-Vos e.a. 2003) will be used to get an impression of the physical
activity pattern.
Background summary
Osteoarthrosis (OA) especially within older adults is one of the most common
chronically disorders. Patients with OA experience pain, stiffness and loss of
joint function.
The incidence of OA in this group is increasing. This development is mainly a
result of an increasing number of older adults and people on average getting
older (Ostendorf e.a. 2002).
An additional reason for the above mentioned increase is the growing number of
people with moderate overweight or obesities, which is considered a risk factor
for OA (RIVM 2004).
Untill now there is no cure for osteoarthritis and to date, conservative
treatment modalities have focused on pain relief and preservation of joint
function (Bell 1999, O`Reilly 1999, Van Baar 1998). In osteoarthritis of the
knee Messier et al. (2004) have shown that a combination therapy results in
improvement of the symptoms. This combination therapy exists of weight loss and
exercise, and leads to a significant improvement of self-reported and
objectively measured functional abilities and pain in patients with knee OA.
Until now insufficient evidence exists of the beneficial effects of weight loss
and therapeutic exercise in the treatment of OA of the hip (Voorlopig CBO
rap/Programmeringstudie ZonMW (2006); Vignon et al., 2006). Similar reasoning
raises the expectation to find a comparable effect to weight loss and exercise
in osteoarthritis of the hip.
Study objective
Obtaining a first impression of the potential effect of a combined lifestyle
intervention (exercise and weight loss), executed in patients with
osteoarthritis of the hip.
Study design
A prospective cohort will be carried out at the department of orthopaedics of
the UMCG in collaboration with the PCRR physiotherapy Hilberdink.
Intervention
The physical exercise therapy will be divided in an individual phase (2 to 3
months) and a group phase (3 months) (total of 6 months). Additionally the
patients will be stimulated to get active, or sustain being active, at home in
order to satisfy the Dutch National Standard Healthy Movement (Kemper et al.,
1999), during the group phase.
Alongside the physical exercise therapy the dietary intervention will take
place in 8 contact moments, executed by a certificated dietary therapist. In
this intervention dietary advice and dietary problems will be discussed.
Study burden and risks
There are no risks in participation in this pilot.
In respect of the safety of physical activity in people with osteoarthritis
there is concluded (most recent review) healthy subjects as wel as patients
with osteoarthritis in general can pursue a high level of physical activity,
provided the activity is not painful and does not predispose to trauma (Vignon
et al. 2006).
Radiographic or clinical osteoarthritis is not a contraindication to promoting
activity in patients who have a sedentary lifestyle.
It is concluded with a high level of of scientific evidence that structured
strengthening exercises have a favourable effect on pain and function in the
sedentary patient with knee osteoarthritis (Vignon et. al. 2006).
Hanzeplein 1
9700 RB Groningen
Nederland
Hanzeplein 1
9700 RB Groningen
Nederland
Listed location countries
Age
Inclusion criteria
Patients of 40 years and older with a calculated body mass index of 25 or more and radiographic and/or clinical evidence of hip osteoarthritis. The osteoarthritis presents with pain in combination with either (a) hip internal rotation >= 15º, pain present on internal rotation of the hip, morning stiffness of the hip <= 60 min or (b) hip internal rotation < 15º, and hip flexion <= 115º.
Exclusion criteria
Patients with severe medical conditions that prevents safe participation in an exercise program (such as angina pectoris, peripheral vascular disease, stroke, congestive heart failure, chronic obstructive pulmonary disease, insulin-dependent diabetes, psychiatric disease, renal disease, renal disease, liver disease, active cancer other than skin cancer, anaemia); symptoms of feet or ankle which could interfere with exercise programs; in case of rheumatic arthritis; an inability to walk without a cane or other assistive device; participation in another research study; inability to finish the study or unlikely to be compliant to the opinion of the clinical staff, because of frailty, illness, co morbidity or other reasons.
Additionally patients who are not able to fill in a questionnaire as a result of language problems or dementia will be excluded. Dementia will be determined with use of the Mini-Mental State Examination score < 24 (Folstein et al., 1975)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL17162.042.07 |
| Other | nog niet bekend |