Objective: How do T cells in cord blood respond to heat shock proteins, allergens and anti-CD3 Are stimulus specific Tregs induced during these responses and can these responses be suppressed by naturally occurring cord blood Tregs in vitro.
ID
Source
Brief title
Condition
- Allergic conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Main study parameters/endpoints: Cytokine production profile, character of
immune cells of full term newborns and functionality of naturally occurring
regulatory T cells as well as induced regulatory T cells.
Secondary outcome
not applicable.
Background summary
Rationale: According to the hygiene hypothesis, the increase in the prevalence
of allergic disorders in the past decades is due to a reduced microbial burden
in childhood in westernized countries. In other immune diseases it has been
shown that regulatory T cells play an important role in controlling the
disease. Our group has shown that regulatory T cells can be induced with heat
shock proteins (HSP). It can be hypothesized that in allergic disease the
regulatory T cells are insufficient in number or in function at birth and that
the immune status can be positively influenced by inducing these Tregs.
Study objective
Objective: How do T cells in cord blood respond to heat shock proteins,
allergens and anti-CD3 Are stimulus specific Tregs induced during these
responses and can these responses be suppressed by naturally occurring cord
blood Tregs in vitro.
Study design
Study design: In vitro study with immune cells isolated from cord blood.
Study burden and risks
Nature and extent of the burden and risks associated with participation,
benefit and group relatedness: Risks and burden for subjects are considered
negligible.
Lundlaan 6
3584 EA, Utrecht
Nederland
Lundlaan 6
3584 EA, Utrecht
Nederland
Listed location countries
Age
Inclusion criteria
full term newborns
high risk: (inhalation or food) allergic pregnant woman
low risk: (inhalation or food) allergy not present with pregnant woman, nor with the to be father or the to be brothers and sisters (now or earlier in life)
Exclusion criteria
gebruik van immuun modulerende medicatie tijdens de zwangerschap
roken tijdens de zwangerschap
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL16498.041.07 |