Influence of individual diet and physiotherapy intervention on the outcome of mitochondrial disease

We assume that nutritional intervention with an individualized diet and optimal
dietary intake in children with a mitochondrial disease supported by aerobic
conditional training improves the energy generating capacity, the clinical
condition and the quality of life in patients.

To improve the quality of life and physical condition of children with
mitochondrial disease.

We will prospectively evaluate and follow up the clinical features, biochemical
characteristics, neuro-imaging and neurophysiological findings, motor
development, exercise tolerance, dietary intake, nutritional state,
anthropometric parameters, energy expenditure, respiratory quotient and the
histological and biochemical findings in muscle in all children. We will
evaluate the state of health, psychomotor development, level of fatigue,
clinical progression and the quality of life with appropriate validated
clinical questionnaires. After detailed evaluation we will offer nutritional
intervention and advise for physiotherapy and general activity including an
individualized exercise program for children with exercise intolerance for the
second half year. Over a year all evaluations will be repeated except for the
muscle biopsy.

A individual diet
Aerobic physiotherapy

The patients may benefit from new insights in energy metabolism of
mitochondrial diseases.