The main objective of this study is to gain knowledge about the biological processes that underlie the effect of cognitive fatigue on learning in middle aged people.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
vermoeidheid
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main outcome measures are performance (mean reaction time and accuracy) and
the blood oxygen level dependent (BOLD) response, a reliable measure for brain
activation, during a working memory and verbal memory task.
Secondary outcome
Mood and fatigue measured by the 'Profile of Mood States' (POMS) questionnaire.
Cortisol levels before and after scanning, measured with a saliva sample
Background summary
Learning is a crucial ability in our professional as well as private life.
Learning disabilities can directly affect the quality of our lives. In our
modern society an increasing number of employees are doing cognitively
demanding work. In addition, working loads tends to increase. This indicates
that often people have to learn new material or procedures while they are
mentally tired. Furthermore, at middle age learning abilities start to decline,
while in their professional lives middle aged people will need extra training
to keep up with the latest technologies. To avoid stress and burnout in middle
age more knowledge is required about the effect of cognitive fatigue on
learning. The present study will investigate the effect of experimentally
induced cognitive fatigue on learning and memory performance and the related
brain activation in healthy middle aged adults.
Study objective
The main objective of this study is to gain knowledge about the biological
processes that underlie the effect of cognitive fatigue on learning in middle
aged people.
Study design
This study has a randomised within-subject design with two age groups
Intervention
Participants will be tested after a 2.5 hour cognitive demanding session
(experimental condition) and after a 2.5 hour cognitive non demanding session
(control condition).
Study burden and risks
Both the intervention (performing cognitive tasks) and the MRI session are
without any known risks.
Dr. Tanslaan 12
6200 MD Maastricht
Nederland
Dr. Tanslaan 12
6200 MD Maastricht
Nederland
Listed location countries
Age
Inclusion criteria
Healthy young adults between 20 - 25 years, and healthy middle aged adults between 50 - 55 years old.
Exclusion criteria
Significant past or present physical or psychiatric illnesses, the use of medication at the moment of inclusion, and MRI contraindications
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL15651.068.07 |