To determine the prevalence of T. whipplei in duodenum and colon in a random population of patients whom will undergo an endoscopy at the VUmc
ID
Source
Brief title
Condition
- Gastrointestinal infections
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Presence of T. whipplei DNA
Secondary outcome
Quantitative determination of T. whipplei DNA
Background summary
Whipple's disease is a very rare infectious disease which can cause several
intestinal and extraintestinal symptoms, varying from mild to very severe. The
disease is caused by a specific bacteria, Tropheryma whipplei. It is difficult
to cultivate the bacteria. Recently a very sensitive and specific real-time PCR
has been developed which can reveal this bacteria. During a pilot study in 20
colonic mucosa biopsy specimens 3 specimens contained T.whipplei-DNA with use
of real-time PCR. At this time nothing is known about the prevalence of T
whipplei in the alimentary tract of humans.
Study objective
To determine the prevalence of T. whipplei in duodenum and colon in a random
population of patients whom will undergo an endoscopy at the VUmc
Study design
Observational study
Study burden and risks
Before endoscopy a questionnaire will be conducted. Height and weight of the
patient will be measured.
During endoscopy two additional intestinal mucosa biopsy specimens will be
harvested besides the usual specimens (normally 4 to 6).
De Boelelaan 1117
1081HV Amsterdam
Nederland
De Boelelaan 1117
1081HV Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
18 years and older
Informed consent
Pre-endoscopy colonic cleansing with Kleanprep® (in case of colonoscopy)
Exclusion criteria
Contraindication for endoscopy
Contraindication for harvesting biopsy specimens
Other pre-endoscopy colonic cleansing than with Kleanprep®
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL21031.029.07 |