Reduce previously learned positive associations with alcoholic drinks by administring propanolol after reactivation of the alcohol-related memory associations.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
alcoholisme (etiologie), probleemdrinken
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Alcohol motivations: scores on a computer task in which participants work for
points which render alcohol.
Secondary outcome
scores on a computertest which assesses alcohol-associations
Background summary
Research has indicated that memories stored in long term memory become
activated after retrieval and then become reconsolidated again. This study
investigates whether it is possible to disturb the memory reactivation of
conditioned associations with an alcoholic drink by administration of
propranolol after reactivation of the alcohol-memory. If it is possible to
disturb alcohol-related associations in this way, this may eventually lead to
new ways to reduce problem drinking.
Study objective
Reduce previously learned positive associations with alcoholic drinks by
administring propanolol after reactivation of the alcohol-related memory
associations.
Study design
Fully experimental: both the learning of the associations and the retrieval
happen in a controlled fashion. We use a double-blind crossover design,
including a session with a placebo and a session with propanolol.
Intervention
disturbance of memory-reactivation of alcohol-related memory associations by
propanolol
Study burden and risks
There is no appreciable risk attached to participation to the study. Alcohol
consumption will remain below legal limits, nevertheless participants are
advised to not drive and use public transport. Use of propanolol is not
associated with known negative side effects other than lowering blood pressure.
We therefore exclude participants with a very low blood pressure.
PO Box 616
6200 MD Maastricht
Nederland
PO Box 616
6200 MD Maastricht
Nederland
Listed location countries
Age
Inclusion criteria
alcohol abuse
Exclusion criteria
high blood pressure
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| EudraCT | EUCTR2007-005929-30-NL |
| CCMO | NL20257.068.07 |