The aim of this study is to determine whether the treatment is effective in reducing symptoms in patients suffering from AVH*s.
ID
Source
Brief title
Condition
- Schizophrenia and other psychotic disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary study parameters/outcome of the study:
PSYRATS / AHRS (voices)
Secondary outcome
SCRS (social comparison rating scale)
BDI (depression)
BAI (anxiety)
PUL (self-efficacy)
BCIS (insight)
PSc (power differential scale)
SERS (self esteem)
MCQ30 (metacognitions)
A motivational inventory
A neuropsychological test measuring memory bias
Emotional stroop (attentional bias)
Background summary
Auditory Verbal Hallucinations (voices) are one of the most persistent and
distressing symptoms in patients suffering from schizophrenia. AVH*s are also
commonly found in other psychiatric disorders. Mostly they are resistant to
medication en therefore they are often responsible for co-morbid symptoms such
as depression and anxiety. Training the memory bias shows hopeful re-sults in
treating patients with AVH*s.
Study objective
The aim of this study is to determine whether the treatment is effective in
reducing symptoms in patients suffering from AVH*s.
Study design
Following a recent pilot a randomised clinical trial is being started. The
effectiveness of this new treatment is being evaluated in patients diagnosed
with schizophrenia, schizo-affective disorder or psychotic disorder NOS
experiencing severe distress from their auditory verbal hallucinations. Results
are being measured by means of inventories and neuropsychological tests.
There will be two conditions:
1) Patients who are in the experimental group receive a 9-session program
following the COMET-protocol. Their treatment as usual (TAU) will be continued
during the program
2) Patients who are in the control group receive treatment as usual (TAU).
Usually this con-sists of sessions with an outpatient therapist and/or a
psychiatrist.
Patients will be subjected to tests and inventories at the start, after 10
weeks and after 18 weeks.
Intervention
The experimental group will have 9 sessions of competitive memory trai ning;
the control group is a waiting list
Study burden and risks
No burden, no documented risks and adverse events.
Oude Haagweg 353
2552 ES Den Haag
Nederland
Oude Haagweg 353
2552 ES Den Haag
Nederland
Listed location countries
Age
Inclusion criteria
Patients suffering from persistent auditory verbal hallucinations in the age 18 to 65. Three particular items of the PSYRATS (Haddock et al. 1999) will be used to screen patients. These items measure frequency of voices (item 1) intensity of distress (item 9) and disturbance of daily functioning (item 10). Patients with results higher than 3 will be included. We defined the hallucinations *persistent* if they still cause distress despite the administration of two different types of antipsychotic medication.
Exclusion criteria
severe abuse of substances, insufficient knowledge and practice of Dutch language.
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL19896.097.07 |