To identify characteristics of the spastic flexor carpi ulnaris muscle (FCU), and the intra-, inter-, and extramuscular connective tissues using high resolution MRI.
ID
Source
Brief title
Condition
- Muscle disorders
- Soft tissue therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Muscle volume, muscle fascicle length, moment arm, amount and nature of the
connective tissues
Secondary outcome
none
Background summary
When performing tendon transfer surgery of spastic muscles in cerebral palsy, a
surgeon is confronted with dilemmas concerning what muscle to transfer, how the
muscle should be mobilized, which route it should take, and at what tension it
should be inserted, considering the individual needs of the patient. There is
not an evidence-based answer to, nor consensus on any of these questions.
Knowledge of the biomechanics of tendon transfer and on the functioning of
spastic muscle is imperative for appropriate surgical planning to meet the
requirements of an optimal muscle balance, and to optimize treatment. However,
estimation of muscle function is difficult because the access to human muscles
is limited to the operation theatre. A non-invasive method to visualize
parameters that determine muscle function would allow for evaluation of
function before and after tendon transfer surgery.
Study objective
To identify characteristics of the spastic flexor carpi ulnaris muscle (FCU),
and the intra-, inter-, and extramuscular connective tissues using high
resolution MRI.
Study design
A prospective observational study.
A series of MRI images of the forearm is gathered twice for both the patients
and the volunteers. Each series will take about 40 minutes.
Study burden and risks
This research aims no direct therapeutic effects for the participants. This
study is deemed to be group-related, because spasticity is a congenital
disorder that is mostly treated at young age; most patients are between 8 and
18 years old. We will only include patients that are 12 years or older. The
non-spastic volunteers are adults. The risks of MRI are small and acceptable.
meibergdreef 9
1100 DD Amsterdam
Nederland
meibergdreef 9
1100 DD Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
Patients with cerebral palsy selected for flexor carpi ulnaris to extensor carpi radialis brevis transfer
A minimum age of 12 years old;Controls:
- Healthy volunteers that have no history of trauma or any other problem to their non-dominant arm
- A minimum age of 18 years old
Exclusion criteria
Not able to understand the written informed consent
Not able to extend the elbow further than 20 degrees of flexion
Unable to lie flat on stomach
Claustrophobia, or unable to lie still for 20 minutes
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL22795.018.08 |