To identify new blood based protein biomarkers for the diagnosis of sepsis.
ID
Source
Brief title
Condition
- Hepatobiliary neoplasms malignant and unspecified
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main endpoint is a list of potential biomarkers differentiating patients
with sepsis and patients with SIRS (diagnostic).
Secondary outcome
Not applicable.
Background summary
Sepsis may be difficult to diagnose and a delay in diagnosis can be fatal. The
mortality of severe sepsis/septic shock ranges from 30% to 70%. Despite all the
research on sepsis, good biomarkers are unavailable.
The discipline of proteomics can potentially identify new biomarkers for
sepsis.
Study objective
To identify new blood based protein biomarkers for the diagnosis of sepsis.
Study design
An extra vial (10 ml blood) will be taken during the study: Prestudy Optimizing
Diagnosis of Community-Acquired Pneumonia (CAP study), during routine sampling
and blood sampling for the CAP study. Within 24-48 hours after admission,
informed consent will be asked to use these materials for diagnostic esearch.
If no consent is given, the materials will be destroyed.
When informed consent is given for participation in the study, the materials
will be analysed with proteomics techniques.
Study burden and risks
Burden: 10 ml extra blood is taken
Risks: no extra risks
Heidelberglaaan 100
3584 CX Utrecht
Nederland
Heidelberglaaan 100
3584 CX Utrecht
Nederland
Listed location countries
Age
Inclusion criteria
1) Admission with suspected Community Acquired Pneumonia
2) Age: adult (18 years and older)
3) SIRS criteria
4) Informed consent
Exclusion criteria
1. Recent admission (<2 weeks), or living in nursing home
2. History of bronchial obstruction or postobstruction pneumonia. Patients with COPD will not be excluded.
3. History of lungcancer or pulmonary metastases
4. AIDS, known or suspected pneumonia caused by Pneumocystis Carinii or known or suspected active tuberculosis.
5. unability to give informed consent
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL23746.041.08 |