Reference value research for instantanious resistance and impulsoscillometrics

At our lungfunctiondepartment - and worldwide as well - airwayresistance has
been measured as a part of the routine on patients by bodyplehysmographia and
impulsoscillometrics (IOS for several years.
As a result of the recent upgrade of the computersoftware, extra information is
available without any major change in the routine measuring procedures or the
used hardware.
Because of the fact that we have to obtain new parameters, we need to measure
reference values in a select group of healthy volunteers.
The absence of reference values according to persons by the age of 5 - 80 years
of age measured by impulsoscillometrics, leaves the impossibility to recognise
or evaluate the measured values according to these patients.

Goal of the research

To investigate whether the newly measured parameters are deviating, these
should be compared to the values of the healty volunteers. The goal to achieve
is the determination of the healthy values as follows:
- Determine reference values for bodyplethysmographia and even more specific
the instantaneous airwayresistance.
- Define the referencevalues and variationcoefficience of the
impulsoscillometric measurement.
- Measure the effect of bronchodilatation on the measured values in both
bodyplethysmographia and impuls-
oscillometrics.

Reference value research

The volunteers experience no complications of the
bodypletysmographia/impulsosccilometric measurements.
Complications of Salbutamol are described in the medicinerepertory as follows:
- Ventolin inhaler, Volumatic and Babyhaler can cause tremor
- Temporary musclecramp is seldom reported
- These effects are being caused by the direct effect on the on the
skeletonmuscles
- These effect depend on the administrated dose and are general to all
beta-sympathicomimatics.
- Mouth and throat irritation can occur
- Within the range of an administrated dose periferal vasodilatation as well as
a smaal compensatory increase of the hartbeat frequently can occur.
- The chance on arythmia will increase on patients with hypocalcemia
- Some patients can show tachycardial symptoms
- defects of the heartbeatfrequency like atriumfibrillation, supreventricular
tachycardia, extrasystols are reported, mostly on patients who are sensitive
for defects od the haertbeatfrequency.
- Haedache, raise of sweat and idiosyncrasic reactions like angio oedemia,
uticavia, bronchospasm, hypertension and collaps are seldom reported.
- Hyperactivity and hallucinations on children are seldom reported.
- Like any other inhalationtherapy one should consider the possibility of
paradoxal bronchospasms (on first appearance of this, the current therapy needs
to be stopped at once and an alternative therapy has to be started)
-cardial complaints like angina pectoris, a recent heart attack (in less than
1/2 year).
- a modarate pumpfunction of the heart
- Claustrophobia
_ Allergic rhinitis
_ Ear-drumpperforation.