By restricting the inclusion on the fMRI studies to participants with deficits on a specific domain we hope to examine the unique neural mechanisms contributing to specific impairments. This will allow us to address the question whether…
ID
Source
Brief title
Condition
- Cognitive and attention disorders and disturbances
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary outcome measures will be the intensity and location of neural
activation during the behavioural tasks in the MRI scanner, and the genotype
on ADHD risk genes.
Secondary outcome
Secondary outcome measures will be the results from the questionnaires, the
interview and the results on neurpsychological tasks.
Background summary
Attention Deficit Hyperactivity Disorder is a neuropsychiatric disorder that
affects 7-10 percent of children between the age of 8-15, making it the most
prevalent childhood disorder. It places a large burden on mental health
services both directly and indirectly, as there is a range of problems
associated with ADHD such as learning disabilities, conduct disorders,
personality disorders, substance disorders and a higher rate of mood and
anxiety disorders.
However, ADHD is a heterogeneous disorder. Individuals with ADHD diverge
greatly in their performance on behavioural tasks, and the neural activation
patterns associated with these tasks are also highly variable between
individuals. We hypothesize that these large individual differences reflect
differences in the neurobiological basis of ADHD in different individuals.
Study objective
By restricting the inclusion on the fMRI studies to participants with deficits
on a specific domain we hope to examine the unique neural mechanisms
contributing to specific impairments. This will allow us to address the
question whether neuropsychological subtypes of ADHD are rected in individual
differences in the neurobiological background of ADHD.
Study design
All subject will be at least 6 years of age. Subjects will be asked to
participate in a neurpsychological assessment (maximum duration 2.5 hrs, an
abbreviated 1 hr version will be used whenever possible), and subjects (or
their parents) will be asked to participate in a structured interwiew( 1.5
hrs.) as well as fill in some questionnaires (45 min.). For school age
subjects, they will also be asked to approache a teacher to fill out a
questionnaire (20 min.). Subjects (and their parents) will be asked to provide
a DNA sample for genetic analysis, by means of saliva or cheekswabs.
A selected group of participants will be asked to participate in a fMRI
scanning session (1hr). Prior to the MRI scan, all child subjects (6-12 yrs)
will participate in a protocolized practice session using a MRI simulator to
desensitize them to the scanner environment, and prevent any anxiousness or
nervousness. Only after acclimating the subject to the scanner environment, so
that both subjects and parents are comportable with the procedure, will the
subject be taken to the actual scanner. As much time will be taken as needed,
but actual practice sessions usually take up to 30 minutes. If the subject or
the parent is uncomfortable with any aspect of the procedure the study will be
cancelled.The same procedure can be used with older subjects if the reseacher
or subject feels this is advisable.
Study burden and risks
There are no known risks associated with MRI acquisition, or any of the
proposed methodologies, and we believe the impact on the subjects will be
minimal. Research into the neurbiological background of ADHD will improve our
insight into the pathofysiology of this disorder, and will facilitate the
future design of new and effective ways to treat this disorder.
Heidelberglaan 100
3584 CX
NL
Heidelberglaan 100
3584 CX
NL
Listed location countries
Age
Inclusion criteria
General inclusion criteria:
1) aged 6-24 years
2) ability to comprehend and speak dutch;Inclusion criteria for subjects with ADHD:
1)DSM-IV (APA, 1994) diagnosis of ADHD
2) scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form(TRF).
3) IQ > 70.;Inclusion criteria for controls:
1) no DSM-IV (APA, 1994) diagnosis
2) no scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form(TRF).
3) IQ > 70.
Exclusion criteria
1)mental retardation (IQ < 70)
2)major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
3)presence of metal objects in or around the body (pacemaker, dental braces)
4)history of or present neurological disorder
5)for individuals over 12 years of age: legal incompetence, defined as the obvious inability to comprehend the information that is presented by the investigator and is outlined in the Information letter and on which the decision to participate in the study is to be based
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL21976.041.08 |