To validate FDG-PET segmentation tools for radiation target volume definition by correlation of CT and FDG-PET volume measurements with histology of nodal metastases of squamous cell carcinoma of the head and neck.
ID
Source
Brief title
Condition
- Other condition
- Malignant and unspecified neoplasms gastrointestinal NEC
- Respiratory tract neoplasms
Synonym
Health condition
plaveiselcelcarcinomen uitgaande van cavum oris, oropharynx, hypopharynx, larynx
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
How accurate are the several FDG-PET segmentation tools in displaying the true
tumor volume?
Secondary outcome
-
Background summary
Progress in radiation oncology enables delivery of radiation treatment with
increasing geometric precision. This requires a re-evaluation of target volume
delineation. This could improve by adding information provided by a molecular
imaging modality such as 18F-fluorodeoxyglucose (FDG)-positron emission
tomography (PET) to the current standard computed tomography (CT). To achieve
this, several FDG-PET segmentation tools have been developed based on phantom
experimentents. The aim of the study is to validate the FDG-PET segmentation
tools by correlation of CT and FDG-PET volume measurements with histology of
nodal metastases of head and neck carcinomas.
When a greater insight in the value of the FDG-PET segmentation tools is
achieved, one will be able to integrate the information provided by FDG-PET in
the target volume definition with a greater certainty. This could have many
advantages, such as an increased accuracy in identifying the tumor. This could
have consequences for the size and the shape of the radiation target volume.
Study objective
To validate FDG-PET segmentation tools for radiation target volume definition
by correlation of CT and FDG-PET volume measurements with histology of nodal
metastases of squamous cell carcinoma of the head and neck.
Study design
An FDG-PET/CT scan is performed prior to the already scheduled neckdissection.
The volume that each FDG-PET segmentation tool identifies as 'tumor volume',
will be validated by measuring the true volume during histological analysis.
Study burden and risks
The burden for the participanting patient is limited to the performance of an
FDG-PET/CT scan of the head and neck region.
Geert Grooteplein 32
6500HB Nijmegen
Nederland
Geert Grooteplein 32
6500HB Nijmegen
Nederland
Listed location countries
Age
Inclusion criteria
•All patients with N+ squamous cell carcinoma of the head and neck, planned for neck dissection
•Age >18 years
Exclusion criteria
•Pregnancy
•Women breast feeding
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL22554.091.08 |