The aim of the present study is to investigate if FFR measurement of a stenosis in a remote coronary artery are influenced by the presence of acute myocardial infarction.
ID
Source
Brief title
Condition
- Coronary artery disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Variability of Fractional Flow Reserve in the non-infarct related artery
between the 2 measurements (immediately
after PPCIof the infarct-related artery vs 5 days- 4 weeks later.
Secondary outcome
Not applicable.
Background summary
It has been questioned if during acute myocardial infarction, flow disturbances
occur in remote
coronary arteries. This means that functional investigations of the severity of
a stenosis in a remote
coronary artery, needs to be postponed for several weeks when microcirculatory
function has normalized.
For patients with an indication for such invasive functional investigations of
that remote artery, it is
mandatory then to undergo a second cardiac catheterisation.
If, however, it would be certain that such measurements could be performed
immediately following primary
PCI of myocardial infarction, this second catheterisation could be avoided.
Study objective
The aim of the present study is to investigate if FFR measurement of a stenosis
in a remote coronary artery
are influenced by the presence of acute myocardial infarction.
Study design
For that purpose, 50 patients presenting with an acute coronary syndrome and
referred for primary coronary
intervention, are investigated. Immediately following successful stent placing
in the infarct related artery,
FFR will be measured in the stenotic, non-infarct related artery. Five - 28
days later, a second measurement
will be performed as in the usual routine whether or not followed by stenting
of that concomitant artery if
indicated by FFR. Comparing FFR values at both sessions, will answer the study
question. All methodology
used is standard methodology.
Study burden and risks
The only extra investigation is the FFR measurement in the non-infarct related
artery immediately following
primary PCI. This extra investigation takes about 10 minutes and is performed
by standard technniques.
Load for the patient and risks are minimal.
Michelangelolaan 2
5623 EJ Eindhoven
Nederland
Michelangelolaan 2
5623 EJ Eindhoven
Nederland
Listed location countries
Age
Inclusion criteria
1) Patients admitted for primary percutaneous coronary intervention of acute
coronary syndrome
2) Presence of a stenosis of at least 50% in a concomitant coronary artery
3) Stable hemodynamic condition
Exclusion criteria
1) Cardiogenous shock or mechanical complication following primaire PCI
2) Extremely tortous or calcified vessels
3) Severe obstructive pulmonary disease
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL22453.060.08 |