To assess if the studied TCD variables of cerebral autoregulation and hemodynamics are abnormal during preeclampsia. And if so, to determine if these changes are large enough to have potential value to determine a threatening cerebral dysfunction in…
ID
Source
Brief title
Condition
- Encephalopathies
- Maternal complications of pregnancy
- Vascular hypertensive disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
TCD autoregulation variables.
Secondary outcome
Laboratory findings
Clinical course
Background summary
Information about the cerebral hemodynamic condition in women with preeclampsia
can be an important factor to determine the indication for pharmacotherapy or
the decision to terminate the pregnancy. At present, these decisions are mainly
based on a clinical (neurological) assessment. Apparently, this assessment is
suboptimal, since many women with preeclampsia have persistent neurological
complaints, such as memory disorders.
Transcranial Doppler sonography is a safe, noninvasive en easy to perform
technique to measure and monitor cerebral hemodynamic changes during
preeclampsia
Study objective
To assess if the studied TCD variables of cerebral autoregulation and
hemodynamics are abnormal during preeclampsia. And if so, to determine if these
changes are large enough to have potential value to determine a threatening
cerebral dysfunction in an individual patient with preeclampsia.
Study design
Observational study, including several measurement sessions during and after
pregnancy complicated with preeclampsia (and a control group). Transcranial
Doppler sonography with additional tests is used to assess the cerebral
hemodynamic condition and autoregulation function.
Study burden and risks
Transcranial Doppler sonography, including the intended provocations, is a safe
and well-tolerated investigation. Every measurement session will take one hour
at most.
Postbus 2040
3000 CA Rotterdam
Nederland
Postbus 2040
3000 CA Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
Preeclampsia
Exclusion criteria
Presence of other central nervous system or vascular disorders.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL21375.078.08 |