To determine whether hypothalamic response to glucose ingestion in patients with anorexia nervosa differs from that in healthy subjects.
ID
Source
Brief title
Condition
- Hypothalamus and pituitary gland disorders
- Eating disorders and disturbances
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Changes in reaction pattern of neuronal activity (as measured with fMRI) in the
hypothalamus in respons to intake of glucose in patients with anorexia nervosa
as compared to healthy controls.
Secondary outcome
n.a.
Background summary
The hypothalamus plays a central role in the regulation of energy intake,
feeding behavior and lipid and glucose metabolism. Previous functional magnetic
resonance imaging (fMRI) provided in vivo evidence for distinct differences in
hypothalamic neuronal activity in lean and obese humans. More recently it was
reported that the hypothalamic response to glucose ingestion in patients with
type 2 diabetes mellitus (DM2) is almost absent as compared to healthy
individuals. Considering the involvement of the hypothalamus in satiation and
satiety, it can be hypothesized that hypothalamic response to energy intake may
be altered in patients with eating disorders. To investigate whether
hypothalamic response to ingestion of glucose is compromised in patients with
extreme weight loss, fMRI of hypothalamic activity will be performed during
ingestion of glucose solution in patients with anorexia nervosa.
Study objective
To determine whether hypothalamic response to glucose ingestion in patients
with anorexia nervosa differs from that in healthy subjects.
Study design
Experimental, case-control studywith an intervention that consists of drinking
200 ml of glucose solution.
Intervention
During MRI scanning, participants drink 200 ml glucose solution through a
plastic tube.
Study burden and risks
Candidates will be screened whether they fulfilll criteria for participation.
Subjects will visit the hospital on a single occasion that takes 1* one hours.
This visit consists of a functional MRI examination of approximately one hour.
During MRI, subjects drink 200 ml of glucose solution. Immediately preceeding
the fMRI, 6 ml blood will be drawn.
The MRI imaging may result in unexpected pathological findings.
Postbus 9600
2300RC Leiden
Nederland
Postbus 9600
2300RC Leiden
Nederland
Listed location countries
Age
Inclusion criteria
Patients:
Female
Anorexia nervosa diagnosed according to DSM-IV criteria.
BMI 17.5 kg/m2 or less
Age 18 - 30 years;Healthy controls:
Female
18.5 kg/m2 <= BMI <= 22 kg/m2
Age 18 - 30 years
Using oral contraceptives
Not on a weight reducing diet
No change in weight of more than 3 kg over the last 2 months
Exclusion criteria
Connected with anorexia nervosa
- Physical condition such that participating in this study is not recommended (as judged by the treating physician of Centrum Eetstoornissen Ursula).;Other
- Any genetic or somatic disease (e.g. fragile X syndrome,) affecting the brain
- Diabetes mellitus or history of diabetes mellitus in first grade relatives
- Any significant chronic disease
- Any substance abuse or addiction according to DSM-IV criteria (except smoking).;Contra-indication to MRI scanning:
- Claustrophobia
- Pacemakers and defibrillators
- Nerve stimulators
- Intracranial clips
- Intraorbital or intraocular metallic fragments
- Cochlear implants
- Ferromagnetic implants
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL23624.058.08 |