Aim 1: To examine the determinants of aggressive behavior in patients with a psychotic disorder. The main focus is on affective responses to psychotic symptoms which can be predictable for aggressive behavior in these patients. Aim 2: In addition,…
ID
Source
Brief title
Condition
- Schizophrenia and other psychotic disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
To investigate affective responses to psychotic symptoms. The outcome
parameters that will be used are: degree of aggression, anxiety, anger,
impulsivity and cognitive insight. Additionally, there will be a focus on the
presence of delusions and/or hallucinations.
Secondary outcome
Psychometric properties of self report questionnaires (various aspects of
reliability and validity)
Background summary
Aggression is a prevalent phenomenon in society. When considering the people
who are most aggressive and dangerous, mentally ill patients are generally
viewed as most aggressive and violent: 61% of the community considers patients
with schizophrenia to be violent (Link et al., 1999). Previous research has
indicated that psychotic patients are more violent than healthy people. In a
review of 28 studies, Flannery (2002) concluded that hospitalized patients show
a repetitive pattern of violent behavior. Also, epidemiological research
indicated that there is a relationship between schizophrenia and violent
behavior. Results of the American Epidemiological Catchment Area study showed
that 3.7% of 10.000 respondents engaged in violent acts during the past year.
Most importantly, 11.3% of the patients with schizophrenia engaged in such
violent acts. Other research has yielded the same results (e.g. Stueve & Link,
1994; Lindqvist & Allebeck, 1990; Modestin & Ammann, 1996; Modestin & Wuermle,
2005; Wessely, 1998; Hodgin, 1992). Therefore it can be concluded that patients
with schizophrenia are at an increased risk for engaging in violent acts. As
such, it is of great importance that underlying determinants of this aggressive
behavior will be investigated and determined. Questions to be answered are: Do
psychotic patients act aggressively out of anxiety. Do they act aggressively
because of anger or do they just respond to hallucinations or delusions? Until
now very few studies have focused on the determinants or mechanisms that might
explain the relationship between aggression and psychotic disorders. This gave
rise to the current research protocol.
Study objective
Aim 1: To examine the determinants of aggressive behavior in patients with a
psychotic disorder. The main focus is on affective responses to psychotic
symptoms which can be predictable for aggressive behavior in these patients.
Aim 2: In addition, the psychometric properties of some self report
questionnaires will be investigated (with a main focus on the VSO).
Study design
The study will take place in several health centers / psychiatric hospitals
(Delta Psychiatric Hospital, De Grote Rivieren, Parnassia Bavo Groep). Patients
will be asked to participate during their first week of hospitalization,
excluding eventual eclusion days. The administration of the interview and
questionnaires will take place on one and the same day. The interview consists
of part B of the SCID and de PANSS and takes 60 minutes. Completion of the
questionnaires will take 40 minutes and these consist of questions about
anxiety (ZBV, BAI), anger (ZAV, DAR, PI), aggression (AQ), impulsivity (BIS11),
cognitive insight (BCIS) and delusions and hallucinations (CHS, VSO, TCOQ).
Moreover, an observation scale will be used for monitoring aggressive behavior
on the ward during the past week (SDAS).
Study burden and risks
Not applicable
Burgemeester Oudlaan 50
3062 PA Rotterdam
Nederland
Burgemeester Oudlaan 50
3062 PA Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
- Men and women between 18-45 years, referred to one of the above mentioned psychiatric hospitals (i.e. DPC, DGR, BAVO, GGZ-D).
- Patients being in their first admission week (or being in the first week after seclusion)
- Patients diagnosed with a psychotic disorder (e.g. schizophrenia, delusion disorder, psychosis NOS)
- Patients who are able to speak, read and understand the Dutch language
- Patients willing to participate in the current research project
Exclusion criteria
- Secluded patients
- Patients with a cognitive and/or mental impairment of handicap that makes self-reports and/or interviews impossible
- Instable somatic illness that makes participation impossible
- Suicidality
- Severe influenced behaviour and/or affect by substance abuse (e.g. drugs, alcohol)
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL21970.097.08 |