Speckle Tracking Imaging is a relatively new echocardiographic technique to quantify the left ventrikular twist and untwisting movement. Several populations like healthy adults and patients with hypertension, myocardial infarction or valvular…
ID
Source
Brief title
Condition
- Congenital cardiac disorders
- Cardiac and vascular disorders congenital
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Peak systolic twist (degree per cm)
Time to peak systolic twist (msec)
Peak negative twist velocity (degree per second)
Time to peak negative twist velocity (msec)
% Untwisting at 20% of diastole (%)
Secondary outcome
Interobserver variability
Intraobserver variability
Background summary
Young adults with congenital valvular aortic stenosis have a diminished
prognosis compared to age-matched healthy subjects despite optimal medical
therapy, follow-up by a specialistic and dedicated team and even despite an
aortic valve replacement. The cause of this difference in prognosis is not well
understood. One explanation is the occurence of heart failure which often
develops at middle age and apperently is not avoided by intervention like
aortic valve replacement. Possibly intervention is too long postponed because
current diagnostic tests like 2D echocardiography do not show the need for
early intervention, because subtle changes in myocardial dysfunction as marker
for future heart failure is missed.
Study objective
Speckle Tracking Imaging is a relatively new echocardiographic technique to
quantify the left ventrikular twist and untwisting movement. Several
populations like healthy adults and patients with hypertension, myocardial
infarction or valvular disease have been studied en data seem promising. It is
not clear whether congenital valvular aortic stenosis can be studied the same
way. If possible, inter- and intraobserver variability and the relationship
between conventional and Speckle Tracking Imaging parameters in relation with
degree of valvular stenosis have to be explored.
Study design
50 healthy volunteers (no stenosis) and 25 patients with congenital valvular
aortic stenosis (mild and moderate to severe stenosis) will be compared. Both
groups will be investigated by a conventional 2D echocardiographic examination
followed by additional imaging suitable for offline analysis with dedicated
software to determine left ventrikular twist and untwisting by Speckle Tracking
Imaging. No invasive measurements will be performed. No bloodsamples ill be
taken. No echo contrast agent will be used. The total examination time will
last 30 minutes.
Study burden and risks
Not applicable
Geert Grooteplein 8
6500 HB Nijmegen
Nederland
Geert Grooteplein 8
6500 HB Nijmegen
Nederland
Listed location countries
Age
Inclusion criteria
Age >18 and < 40 years old
Congenital aortic valve stenosis with AVA <1.0 cm2, 1.0-1.5 cm2 or 1.5-2.0 cm2
LVEF >/= 55%
Exclusion criteria
LVEF < 55%
Non-valvular aortic stenosis
Hypertrophic Obstructive CardioMyopathy
Residual coarctation aorta
Moderate or severe aortic regurgitation
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL24818.091.08 |