To compare the MC with the UK working party diagnostic criteria (UKC) and clinical diagnosis and to refine the MC into a more convenient and reliable set of criteria.
ID
Source
Brief title
Condition
- Allergic conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Sensitivity and specificity (thus diagnostic accuracy) of the MC and UKC.
Secondary outcome
Positive and negative predictive value of the MC and UKC
Background summary
During the last decades various lists of diagnostic criteria for atopic
dermatitis (AD) have been proposed and partially validated. However, there is
discrepancy between the current definition of atopy, and how that is applied in
diagnosing AD. In order to comply with the new definition of AD, the
millennium criteria (MC) were developed in which presence of allergen specific
IgE is a mandatory criterion.
Study objective
To compare the MC with the UK working party diagnostic criteria (UKC) and
clinical diagnosis and to refine the MC into a more convenient and reliable
set of criteria.
Study design
A prospective cohort study, hospital based.
Study burden and risks
This research requires only one study visit. During this visit of approximately
30-45 minutes the patient will be physically examined (mainly inspection) by
two dermatologists and the study investigator, successively. If not previously
performed a phadiatoptest will be done to for test allergen specific IgE.
We expect no considerable effects of participating in this study other than the
risk associated with drawing bloodsamples.
Meibergdreef 9
1105 AZ Amsterdam
Nederland
Meibergdreef 9
1105 AZ Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
Included are patients that:
* Are consecutive new patients from the outpatient clinic of the AMC
* either have the diagnosis of atopic dermatitis (AD) or the diagnosis of AD is considered in the differential diagnosis made by resident or dermatologist.
* Understand and are willing to sign the written informed consent
Exclusion criteria
Patients unwilling to participate
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL24845.018.08 |