To assess whether pacing from the right ventricular outflow tract, the right ventricular apex or combined pacing shows difference in right and left ventricular ejection fraction and asynchrony.
ID
Source
Brief title
Condition
- Cardiac arrhythmias
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
This is an observational study in a limited population of patients previously
included in the PROUST study, to assess the feasibility of the quantitative
blood-pool SPECT. The study is designed as proof of principle that QRS duration
and cardiac functioning in RV paced patients are related.
Secondary outcome
not applicable
Background summary
Ventricular pacing is an accepted therapy for patients with brady-arrhythmia.
Conventionally the ventricular pacing lead is placed in the right ventricular
apex (RVA). However, recent data suggest that pacing in this site can arouse
adverse effects on left ventricular function (LVF) and prognosis of the paced
patient. Because of a supposed more physiological activation of the left
ventricle right ventricular outlow tract (RVOT) pacing has been introduced. The
PROUST study was designed to investigate the effects of RVA, RVOT and RVA/RVOT
combined (RVC) pacing on echocardiographically determined LVF, QoL and walking
distance in patients with spontaneous or induced AV block with chronic atrial
fibrillation. This study showed no differences after a 2 month cross-over
period
Study objective
To assess whether pacing from the right ventricular outflow tract, the right
ventricular apex or combined pacing shows difference in right and left
ventricular ejection fraction and asynchrony.
Study design
All patients will undergo gated blood-pool SPECT to assess LV and RV volume,
LVEF, RVEF, interventricular and LV intraventriuclar mechanical delay as well
as phase analysis of both ventricles will be measured by gated blood-pool
SPECT. Images will be acquired during pacing from the RVA, RVOT and RVC.
Study burden and risks
one outpatient clinic visit, during which blood-pool SPECT imaging will be
performed
koekoekslaan 1
3435 CM, Nieuwegein
Nederland
koekoekslaan 1
3435 CM, Nieuwegein
Nederland
Listed location countries
Age
Inclusion criteria
participation in PROUST study
Exclusion criteria
not applicable
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL24566.100.08 |