1) To investigate the relative contribution of different neurocognitive dysfunctions toADHD.2) To identify potential baseline EEG/MRI markers of different neurocognitive functions in ADHD children and healthy controls.
ID
Source
Brief title
Condition
- Cognitive and attention disorders and disturbances
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The difference between children with ADHD and matched healthy controls on the
relationship between brain and cognition.
Secondary outcome
not applicable
Background summary
Decades of research have established well-replicated findings of several
neurocognitive deficits in attention-deficit/hyperactivity disorder (ADHD),
leading to well-developed neurocognitive models of ADHD. Moreover, neuroimaging
and electrophysiological studies have revealed consistent evidence for abnormal
brain structures as well as deviant brain activity in ADHD. However, only
recently, research is directed to the integration of different neurocognitive
models within one study in order to elucidate their relative contributions to
ADHD. Furthermore, studies that directly link brain abnormalities to
neurocognitive dysfunctions are lacking. This case-control study focuses on
neurocognitive dysfunctions and EEG/MRI markers in ADHD.
Study objective
1) To investigate the relative contribution of different neurocognitive
dysfunctions toADHD.
2) To identify potential baseline EEG/MRI markers of different neurocognitive
functions in ADHD children and healthy controls.
Study design
Patient control study
Study burden and risks
Risks or side-effects are not expected. The burden for the subjects consists of
a screening session (30 min), intake (60 min) and two experimental sessions (70
and 125 min). The benefit involves extended knowledge about ADHD. Because ADHD
is primarily a psychiatric disorder of childhood, children will form the target
population of the present study.
Reinier Postlaan 10
6500 HB Nijmegen
Nederland
Reinier Postlaan 10
6500 HB Nijmegen
Nederland
Listed location countries
Age
Inclusion criteria
Age between 8 and 15 years
IQ >= 80;An additional criterium for the ADHD group:
Psychopharmaca-naive, or using psychostimulants/atomoxetine
Exclusion criteria
Currently intensive (i.e. weekly) individual or group psychotherapy
Regular use of medication other than psychopharmaca
Diagnosis of one or more of the following comorbid psychiatric disorders: Major depression, Bipolar disorder, Psychotic disorder, Chronically motor tic disorder or Gilles de la Tourette, Conduct disorder, Autism spectrum disorders, Eating disorders.
Neurological disorders (e.g. epilepsy) currently or in the past
Cardiovascular disease currently or in the past
Participation in another clinical trial simultaneously
Metal parts in the body;An additional exclusion criterium for the control sample is diagnosis of ADHD
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL24151.091.08 |