We aim to create a large cohort of patients with early-onset CAD to study sequence variations resulting in CVD. Initially, by validating sequence variations in candidate genes and loci found by our PAS pedigrees work, GWAS studies and Cardiochip…
ID
Source
Brief title
Condition
- Cardiac and vascular disorders congenital
- Arteriosclerosis, stenosis, vascular insufficiency and necrosis
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Establish a large prospective cohort of subjects with early onset CAD to
determine the significance of a wide range of genetic variations in the
development of atherosclerotic cardiovascular disease.
Secondary outcome
Identify index cases of pedigrees for PAS Pedigrees protocol
Background summary
Myocardial infarction is a leading cause of mortality and morbidity worldwide.
A number of well validated risk factors have been identified over the last
decades for cardiovascular disease (CVD) such as smoking, hypertension,
diabetes, obesity and dyslipidemias. In addition to these traditional factors,
several studies have confirmed that a family history of CVD is an independent
risk factor. However, the genetic basis for CVD is still not completely
understood. Coronary artery disease (CAD) in younger individuals have been
associated with substantially greater heritability. Thus, early-onset CAD is a
promising phenotype for mapping of genetic risk factors for CVD.
Study objective
We aim to create a large cohort of patients with early-onset CAD to study
sequence variations resulting in CVD. Initially, by validating sequence
variations in candidate genes and loci found by our PAS pedigrees work, GWAS
studies and Cardiochip data. Ultimately, in the near future when whole genome
sequencing is widely available for a lower price by whole genome sequencing.
Study design
Cohort study
Study burden and risks
The burden for participants is a venipuncture. The risks are haematomas or
bleeding.
Meibergdreef 15
1105 AZ Amsterdam
NL
Meibergdreef 15
1105 AZ Amsterdam
NL
Listed location countries
Age
Inclusion criteria
Coronary Artery Disease under the age of 65 in women and 55 in men.
Exclusion criteria
none
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL29717.018.09 |