- To assess the number of de novo aneurysms in patients who underwent therapeutic ICA occlusion more than 5years ago.- To assess infarct load in patients who underwent therapeutic ICA occlusion more than 5 years ago.- To evaluate the distribution of…
ID
Source
Brief title
Condition
- Central nervous system vascular disorders
- Aneurysms and artery dissections
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- De novo aneurysms on magnetic resonance angiography (MRA)
- Whole brain and regional CBF (ml/100 grams/min)
Secondary outcome
- Infarction on T2-weighted MRI and Fluid Attenuated Inversion Recovery (FLAIR)
Background summary
Large (>10 mm) and giant (>25 mm) symptomatic internal carotid artery (ICA)
aneurysms are treated by occlusion of the ICA if tolerated. The long-term
effect of this treatment remains unclear. With only one patent ICA, it is
possible that patients develop a delay in or lack of perfusion on the side of
the ICA occlusion, suffer from more (subclinical) infarctions caused by lower
regional perfusion, or develop new intracranial aneurysms by the change in
hemodynamics. Arterial Spin Labeling (ASL) is a relatively new and non-invasive
magnetic resonance imaging (MRI) technique for the visualisation and
quantification of cerebral perfusion.
Using selective ASL it is also possible to image the flow territories of the
major brain feeding arteries independently (the internal carotid arteries and
the basilar artery).
Study objective
- To assess the number of de novo aneurysms in patients who underwent
therapeutic ICA occlusion more than 5
years ago.
- To assess infarct load in patients who underwent therapeutic ICA occlusion
more than 5 years ago.
- To evaluate the distribution of cerebral perfusion over the left and right
hemisphere in patients who underwent therapeutic ICA occlusion more than 5
years ago.
Study design
Follow-up cohort study
Study burden and risks
This study is conducted using a non-invasive imaging modality: MRI. There is no
risk associated with participation. If abnormalities on the MR images are
apparent, a specialist will be consulted.
Meibergdreef 9, postbus 22660
1100 DD Amsterdam
Nederland
Meibergdreef 9, postbus 22660
1100 DD Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
Therapeutic ICA occlusion in Tilburg or Amsterdam between January 1996 and August 2004
Exclusion criteria
The presence of metal in the body (e.g. osteosynthetic material, pacemaker, artificial cardiac valves); claustrophobia; surgery performed in the area of measurement with the use of neurosurgical clips.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL30217.018.09 |