Our primary objective is to determine the incidence of EPS after kidney transplantation in patients previously treated by PD. We hypothesize that there is an increasing incidence of symptomatic and asymptomatic EPS after kidney transplantation.
ID
Source
Brief title
Condition
- Peritoneal and retroperitoneal conditions
- Renal disorders (excl nephropathies)
- Renal and urinary tract therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The incidence of EPS, both clinically evident and silent, after kidney
transplantation in patients previously treated by PD.
Secondary outcome
Factors predisposing to EPS in patients after kidney transplantation.
Background summary
Encapsulating peritoneal sclerosis (EPS) is a serious complication in patients
on peritoneal dialysis (PD). Diffuse peritoneal sclerosis leads to encasement
of the small bowel. Clinical features of EPS including recurrent abdominal
pain, nausea, vomiting, anorexia, bowel obstruction and severe weight loss.
Total parenteral nutrition is often needed and in severe cases surgical
treatment is indicated. Mortality rate is high because of malnutrition,
infections, and surgical complications. The diagnosis of EPS is difficult and
mainly based on clinical signs and symptoms. Radiological investigations play a
significant role in confirming a suspected diagnosis of EPS. Recently, a
remarkable increase in EPS cases was observed, especially EPS manifesting in
the first year after kidney transplantation. However, the exact incidence of
post-transplant EPS in PD patients and its risk factors are unknown and have
not been studied prospectively.
Study objective
Our primary objective is to determine the incidence of EPS after kidney
transplantation in patients previously treated by PD. We hypothesize that there
is an increasing incidence of symptomatic and asymptomatic EPS after kidney
transplantation.
Study design
Prospective, observational study.
Study burden and risks
To make the diagnosis we will use a questionnaire, blood test, abdominal
ultrasound, and abdominal computed tomography. These investigations will be
performed at baseline, and after 6, and 18 months. Before kidney
transplantation a peritoneal equilibration test will be performed. During
kidney transplantation procedure, a biopsy of the parietal peritoneum will be
obtained.
Heidelberglaan 100
3584 CX Utrecht
Nederland
Heidelberglaan 100
3584 CX Utrecht
Nederland
Listed location countries
Age
Inclusion criteria
Patients with ESRD who are treated by PD and are about to undergo a kidney transplantation in the University Medical Center Utrecht.
Exclusion criteria
Patients who are unable to give informed consent.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL24646.041.08 |