Aim is to establish the relation between skin AGEs, measured as skin-autofluorescence, and diastolic dysfunction. Primary Research Questions1. Is there a relation between skin-autofluorescence and the severity of diastolic dysfunction in patients…
ID
Source
Brief title
Condition
- Heart failures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Skin-autofluorescence
Diastolic function
Secondary outcome
Dabetes mellitus
NYHA-functional class
Renal dysfunction
Background summary
Approximately 40-70% of patients with heart failure have diastolic dysfunction
with preserved systolic function. The pathophysiology of diastolic dysfunction
is only partly known. Advanced glycation end-products (AGEs) are carbohydrate
and lipid dependent modifications of protein, formed by oxidative or
non-oxidative reactions. These modifications affect the physiological
properties of proteins in the extracellular matrix, such as charge,
hydrophobicity, turnover and elasticity. We hypothesise that accumulation of
AGEs is involved in the development of diastolic dysfunction.
Study objective
Aim is to establish the relation between skin AGEs, measured as
skin-autofluorescence, and diastolic dysfunction.
Primary Research Questions
1. Is there a relation between skin-autofluorescence and the severity of
diastolic dysfunction in patients undergoing routine echocardiography for
diastolic function?
Secondary Research Questions
1. Is there a relation between skin-autofluorescence, diastolic function, and
the presence of diabetes mellitus?
2. Is there a relation between skin-autofluorescence, diastolic function, and
NYHA function class?
3. Is there a relation between skin-autofluorescence, diastolic function, and
the presence of renal dysfunction?
Study design
This is a cross-sectional study in patients visiting our clinic for routine
echocardiografic examination. During the echocardiogram, AGE's in the skin will
assessed by measuring the skin-autofluorescence. Also, a few questions
concerning the clinical condition of the patient will be asked. Additional
parameters, including the presence of diabetes mellitus or renal dysfunction,
will be collected from the medical records of the patients. Along with the
results from the echocardiografic examination, these will be used to study the
relationship between acummulation of AGEs and diastolic dysfunction.
Study burden and risks
Burden and risks associated with participation are minimal. Participation costs
approximately 5 minutes, and measuring skin-autofluorescence is not associated
with any risks.
Postbus 30001
9700 RB Groningen
Nederland
Postbus 30001
9700 RB Groningen
Nederland
Listed location countries
Age
Inclusion criteria
Signed Informed consent
Age > 18 years
Exclusion criteria
atrial fibrillation at time of echocardiography
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL24753.042.08 |