Objectives: To optimize SSEP recording methods to improve diagnostic procedures in myoclonic disorders. More precisely, to determine whether enhanced N35 potentials are more commonly found using multichannel (64 channels) SSEP versus conventional (5…
ID
Source
Brief title
Condition
- Movement disorders (incl parkinsonism)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Main study parameters/endpoints:
Part A: localization and amplitude of N35 potentials using multichannel SSEP
compared to results of standard SSEP in individuals with a cortical myoclonic
disorder and in healthy subjects. Part B: identical to part A for subcortical
myoclonus and dystonia.
Secondary outcome
nvt
Background summary
Rationale: Currently, clinical history and physical examination are the basis
to discriminate between myoclonic disorders. However, clinical criteria are
usually not sufficient. To differentiate between myoclonic disorders,
somatosensory evoked potential (SSEP) measurement can be helpful. In previous
studies, a giant potential was found in cortical myoclonus, and a less enlarged
potential in subcortical myoclonus and dystonia, as compared to healthy
controls. Large intersubject variability however reduces the predictive value.
Multichannel SSEP will probablymay reduce intersubject variability and shorten
diagnostic procedures in these patients.
Study objective
Objectives: To optimize SSEP recording methods to improve diagnostic procedures
in myoclonic disorders. More precisely, to determine whether enhanced N35
potentials are more commonly found using multichannel (64 channels) SSEP versus
conventional (5 channels) SSEP in patients with cortical myoclonus.
Furthermore, to determine which electrodes represent the largest amplitude of
the enhanced N35 potential in patients compared to healthy controls. Also, to
observe possible differences in the influence of medication on amplitude and
latency of N35-measurement. And finally, to investigate differences in
amplitude and localization of potentials between patients diagnosed with
cortical myoclonus, subcortical myoclonus and dystonia.
Study design
Study design: Case-control study
Study burden and risks
Patients will undergo one site visit, during which standardized clinical
evaluations will be performed with the aid of clinical scales and videos. They
will be checked for other neurological conditions. During the same visit,
patient will undergo a SEPP measurement recording. Healthy subjects will
undergo the same procedure.
The proposed investigation bears virtually no risks and is usually well
tolerated. Eventually, the aim of this study is to improve and shorten the
diagnostic process of myoclonic disorder. Healthy controls will have no special
benefits.
Pb 22660
1100 DD Amsterdam
NL
Pb 22660
1100 DD Amsterdam
NL
Listed location countries
Age
Inclusion criteria
Group A: patients with strong clinical suspicion of cortical myoclonus
Group B: patients with strong clinical suspicion of dystonia
Group C: patients with strong clinical suspicion of subcortical myoclonus
Group D: matched healthy controls
Exclusion criteria
Other neurological disorders than the above mentioned.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL29978.018.09 |