(1) to determine the psychiatric status (ADHD and ODD/CD) for the second time in participants from ADHD and control families about 5 years after the first assessment. The participants will be between 10 and 23 years of age now; (2) to determine the…
ID
Source
Brief title
Condition
- Cognitive and attention disorders and disturbances
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Multivariate statistics will be applied. The data will be combined with those
of Essen and Gent for the genetic analyses. If 322 trios of patients with both
ADHD and SUD are available, this will offer 80% power or more to detect alleles
for SUD that increase the risk with 70% (a relatively large risk of 1.7) using
an alpha of 0.05.
Secondary outcome
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Background summary
ADHD is associated with an increased risk for substance abuse disorder (SUD) in
adolescence and adulthood. It is not clear what the exact role of ADHD is on
the pathway from legal drugs (nicotine and alcohol) to illegal substances. Also
not clear is the role of comorbid disorders like ODD and CD on SUD. Rsearch in
the VS suggests that treatment for ADHD with medication will diminish the risk
for later SUD. There is no data on this in Dutch children. Genetic factors
(possibly shared) are important in both ADHD and SUD. ADHD in combination with
SUD might form a more homogeneous genetic subgroup of ADHD patients, which
would enhance the finding of risk genes for both ADHD and SUD.
Study objective
(1) to determine the psychiatric status (ADHD and ODD/CD) for the second time
in participants from ADHD and control families about 5 years after the first
assessment. The participants will be between 10 and 23 years of age now; (2) to
determine the presence of SUD in participants from ADHD and control families;
(3) to document the treatment history (medicational and non-medicational) of
participants with ADHD; (4) to perform association analyses on the candidate
genes for ADHD and SUD in the ADHD families.
Study design
1. contacting the participants of the baseline assessment, informing them about
the current study and asking informed consent.
2. collecting the questionnaire data, either by telephone or during visits.
3. data-analyses and reportage.
Study burden and risks
Collecting the questionnaire data will take about 1.5-2 hours for each
participant.
Postbus 9101
6500 HB Nijmegen
Nederland
Postbus 9101
6500 HB Nijmegen
Nederland
Listed location countries
Age
Inclusion criteria
Probands were required to have the combined subtype of ADHD and at least one additional sibling and one parent should be available for participation. Children were between 5 and 18 years of age.
Exclusion criteria
(1) IQ<70, (2) a diagnosis of schizophrenia or autism that might confound the diagnosis of ADHD, and (3) neurological disorders such as epilepsy and brain injury, as well as any genetic or medical disorder associated with externalising behaviors that might mimic ADHD.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL23908.091.08 |