Validation of the ability to use ETCO2 as a patient-specific marker for the quality of flow related to the depth of compressions. Control using invasive bloodgas values.
ID
Source
Brief title
Condition
- Other condition
- Cardiac disorders, signs and symptoms NEC
- Vascular therapeutic procedures
Synonym
Health condition
Reanimatie (opwekken kunstmatige boedsomloop met compressies)
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
A correlation between end-tidal CO2 and bloodgas values (arterial and/or
venous) > 0.8, based on a series of 5 measurements. Correction for compression
activities (force- and depth) as well as age, thoracic cage diameter
co-morbidity and intravascular volume. A correlation of ETCO2 and compression
depth > 0.7.
Secondary outcome
none
Background summary
External chest compressions (i.e. sternal compression) is used to create an
intra-thoracic pressure wave suitable for generating an artificial circulation.
In current clinical practice, there are no effective or efficient methods which
reflect on flow and which allow suitable biofeed back to direct the quality of
compressions. This biofeedback may allow force used in chest compressions to be
decreased, avoiding needless thoracic trauma.
The function of this investigation is to determine whether patient specific
end-tidal CO2 monitoring is a useful biofeedback modality for controled
compression depth, -force and corelates with invasively measured bloodgas
parameters. Many of the underlying data is already available in the standard
monitoring system used during resuscitations.
During a regular resuscitation session, two bloodgasses are taken for
diagnostisch and therapeutic use. During this investigation, 5 extra
bloodgasses will be determined, preferably by indwelling (arterial or venous)
lines.
Study objective
Validation of the ability to use ETCO2 as a patient-specific marker for the
quality of flow related to the depth of compressions. Control using invasive
bloodgas values.
Study design
Open, prospective, non-randomized study using a convenience sample.
During resuscitation, the universal algorithm refers to cycles of 2-3 minutes.
In the EZ we have a maximum of 10 cycles. During these cycles 2 bloodgasses
will be analyzed for therapeutic and diagnostic reasons. During the
investigation additional (5) bloodgasses will be performed and documented to
allow time-sensitive comparison with ETCO2 monitoring.
Using a computer model, potential predictive value of the ETCO2 will be
calculated.
Study burden and risks
These patients are being resuscitated. The intervention described in this study
proposal increaces the number of blood gas determinations from 2 to 7 per full
resuscitation session of 40 minutes. This sampling may be possible from
indwelling lines, and otherwise requires punctures. Only the systemic use of
anticoagluatory medication seems to entail a relevant risk of bleeding.
Hilvarenbeekseweg 60
5022 GC Tilburg
NL
Hilvarenbeekseweg 60
5022 GC Tilburg
NL
Listed location countries
Age
Inclusion criteria
Patients being or reaching resuscitation including external chest compressions
Exclusion criteria
Do not attempt resuscitation orders
Previous refusal to participate in the study
Age < 18 years old
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL30847.008.09 |