The overall aim of the study is to enrich the database of the Dutch IMAGE samples with (1) structural magnetic resonance imaging (sMRI) and functional MRI (fMRI) data; (2) follow-up data of clinical status (ADHD symptoms and relevant comorbidities)…
ID
Source
Brief title
Condition
- Cognitive and attention disorders and disturbances
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Assessments will be scheduled 5 to 6 years after the baseline assessments. sMRI
(30 min) and fMRI (60 min, while presenting the stop-task and a spatial working
memory task) data will be acquired. Phenotyping will follow similar procedures
as at baseline, and include a semi-structured investigator-based interview to
categorically classify ADHD, and questionnaires to obtain dimensional scores of
ADHD symptoms and related comorbidity. Outside the scanner, 8 other
neuropsychological tasks will be administered to the children (set-shifting,
verbal working memory, time reproduction, motor timing, motor control, motor
speed, intelligence, and positive and negative reinforcement). Parents will be
assessed using the same 10 neuropsychological tasks outside the scanner, and be
phenotyped using questionnaires.
Secondary outcome
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Background summary
Attention-deficit / Hyperactivity Disorder (ADHD) is a neuropsychiatric
disorder which involves substantial involvement of genetic factors as indicated
by adoption and twin studies. In the context of the International Multisite
ADHD Genetics (IMAGE) project, an ongoing genetic initiative funded by the
National Institute of Mental Health in 2002, extensive phenotypic,
endophenotypic (neuropsychological) and genotypic information of about 5758
subjects from 1401 ADHD families in 8 countries in Europe has been collected. A
substantial subsample (1625 subjects from 388 families) of this database has
been collected in the Netherlands by research groups in Nijmegen, Amsterdam and
Groningen. The Dutch database also includes phenotypic and endophenotypic data
from 271 healthy control children from 147 families. In 2006 the Genetic
Association Information Network (GAIN) initiative of the National Institute of
Health granted the IMAGE consortium the genotyping of 600,000 single nucleotide
polymorphisms (SNPs) to perform a genome-wide association scan (GWAS) in 958
(315 from the Netherlands) trios of ADHD-affected children and their parents
from the IMAGE cohort.
Study objective
The overall aim of the study is to enrich the database of the Dutch IMAGE
samples with (1) structural magnetic resonance imaging (sMRI) and functional
MRI (fMRI) data; (2) follow-up data of clinical status (ADHD symptoms and
relevant comorbidities) using questionnaires and a semi-structured interview,
and (3) neuropsychological endophenotypes of both probands and siblings of ADHD
families and controls; in addition, (4) comparable phenotypic and
neuropsychological endophenotypic data of the parents of children with ADHD and
of control children will be collected. This resource will be made publicly
available. By having access to the genotypes of the GWAS, this will allow us
and other investigators to clarify the consequences of ADHD risk alleles at the
level of both brain function and structure, to increase our understanding of
the pathophysiology of ADHD, and to examine the role of genes in the
persistence and outcome of ADHD over time.
Study design
Follow-up of ADHD and control cohort assessed between 2004 and 2006 to be
re-assessed again between 2009 and 2011.
Study burden and risks
Discomfort associated with recalling psychiatric symptoms and MRI scanning
(such as exposure to loud noise and being in a small closed space which may
elicit claustrophobia) may be experienced. Some study subjects may benefit from
early identification of previously unrecognized psychiatric illness or
psychological deficits. Also in case anomalies are detected during MR scanning,
parents or affected individuals, respectively, and their general practitioner
will be alerted and all efforts will be made to assure diagnostic work-up and
appropriate treatment.
Postbus 9101
6500 HB Nijmegen
NL
Postbus 9101
6500 HB Nijmegen
NL
Listed location countries
Age
Inclusion criteria
Previous inclusion criteria: ADHD-families: at least one proband with the combined subtype of ADHD and at least one sibling and one parent available for testing. Children between the ages of 5 and 18 were included.
Control-children: no ADHD and no ADHD in their first-degree relatives. Children between the ages of 5 and 18 were included.;For the current follow-up: all children are contacted and tested again, regardless of previous in- and exclusion criteria allowing for studying remitted cases of ADHD (or new ADHD cases in the control group).
Exclusion criteria
(1) IQ<70, (2) a diagnosis of schizophrenia or autism that might confound the diagnosis of ADHD, and (3) neurological disorders such as epilepsy and brain injury, as well as any genetic or medical disorder associated with externalising behaviors that might mimic ADHD.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL23894.091.08 |