The objective of the study is to protract the sleep related complaints of patients with a carotid body tumor, especially with patients with a carotid body tumor. Patients will be divided in groups based on having a single sided or double sided GCT.…
ID
Source
Brief title
Condition
- Neoplastic and ectopic endocrinopathies
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
results of the sleepregistration with polysomnografy
results of the sleep questionnaires
results of the sleepregistration at home
results of the resting energy expenditure
24 hour meassurements of the blood pressure and pulse
results op the quality of life questionnaires
chemoreflex meassurements
lungfunction
examination of the blood
Secondary outcome
-
Background summary
Patients with head and neck paragangliomas have substantial sleep related
complaints. the existence of a glomus caroticum tumor is associated with an
increased sleepiness during the day. the carotid body is a chemoreceptor wich
meassures the arteriel oxygen saturation en contributes to the regulation of
the ventilation. A carotid body tumor may cause a disruption of the function of
the chemoreceptor, wich may cause a less adequate ventiatoiry respons in
hypoxic circumstances. This may contribute to an increase in sleepiness during
the day with patients with head and neck paragangliomas, especially with the
patients with a carotid body tumor.
Study objective
The objective of the study is to protract the sleep related complaints of
patients with a carotid body tumor, especially with patients with a carotid
body tumor. Patients will be divided in groups based on having a single sided
or double sided GCT. And there will be a subdivision whterher or not the
patient has been operated on the single- or double sided GCT.
Study design
the study is cross-sectional in design, to examine the causes of sleep related
complaints with the help of polysomnografy
Study burden and risks
To participate in the study patients and control persons will be staying in the
hospital for one day to perform the polysomnografy. They will have to visit the
LUMC to have an instruction how to perform the sleep registration at home, they
will have to visit the LUMC to bring back the equipment and they will were an
actiwatch for two weeks. All of the meassurements are safe and non-invasive.
Albinusdreef 2
2333 ZA Leiden
Nederland
Albinusdreef 2
2333 ZA Leiden
Nederland
Listed location countries
Age
Inclusion criteria
patients with carotid body tumors
informed consent
declaration of insent
Exclusion criteria
pregnancy
diagnosed sleeping disorder
instable regulation of blood pressure with respect to medication use
chronic use of sleep medication
psychotropic medication
existence of secondary paraganglioma of the thorax, abdomen or pelvis
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL24518.058.08 |