If certain combinations of micro RNA's that are predictive for recovery exist, they can be improtant for prognostic reasons and play a role in postponing device implantation. It may also help in choosing the right pharmaceutic regiment.
ID
Source
Brief title
Condition
- Heart failures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Upregulation of certain mRNA's in patients with (de novo) systolic heartfailure>
Changes in this upregulation in recovery?
Value in predicting recovery?
Secondary outcome
-
Background summary
A new way to study gene expression in heartfailure is to look at micro-RNA's.
It's possible that there are certain combinations of micro RNA's that are
helpfull in the predicion of recovery.
We know that there are certain mRNA's that are upregulated in patients with
heartfailure and that there is clustering of several mRNA's in certain patient
groups. The exact meaning in recovery /deterioration is yet unknown.
Study objective
If certain combinations of micro RNA's that are predictive for recovery exist,
they can be improtant for prognostic reasons and play a role in postponing
device implantation. It may also help in choosing the right pharmaceutic
regiment.
Study design
Prospective study of all patients with first presentation systolic
heartfailure. (In- and outpatient clinic)
Study burden and risks
No extra risk or burden for the patient.
Meibergdreef 9
1105 AZ Amsterdam
NL
Meibergdreef 9
1105 AZ Amsterdam
NL
Listed location countries
Age
Inclusion criteria
Systolic heartfailure
Exclusion criteria
EF > 40%
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL30055.018.09 |