prevalence and etiological factors of testicular adrenal rest tumours in children and adolescents with congenital adrenal hyperplasia (CAH) - a multicentre study

In adult male patients with congenital adrenal hyperplasia (CAH) benign
testicular adrenal rest tumours (TART) is a common cause of infertility. The
prevalence in the adult population is up to 94%. It is thought that the
tumours consist of aberrant adrenal rests within the testes and that these
tumours may already be present in childhood. The presence of TART in children
is described mostly in case reports and only a limited number of studies
describe its prevalence in larger populations of children and adults .

1. Study of the incidence of TART in male CAH children in a multicentre
setting
2. Detection of predisposing factors for tumour growth.
3. Evaluating of gonadal function in male CAH children with TART

Prospective, multicentre

Ultrasonographic examination of the testes once per year.

Ultrasound is a non-invasive investigation without expected complaints for the
patient. In our own centre testicular ultrasound is already used within our
yearly follow up programme. Blood collection is also part of the routine
programme. Early detection of TART may help to prevent tumour growth and
infertility in adulthood