The objective of the study is to investigate the changes in cortical connectivity patterns, as measured by resting-state fMRI, as a consequence of the use of transcranial direct current stimulation.
ID
Source
Brief title
Condition
- Movement disorders (incl parkinsonism)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The changes in spontaneous low frequency fluctuations of the blood oxygenation
level dependent (BOLD) signal throughout the brain as measured via functional
magnetic resonance imaging (fMRI).
Secondary outcome
none
Background summary
Transcranial direct current stimulation (tDCS) is a promising technique to
non-invasively study and alter human brain function by means of sending a weak
direct current through the skull and brain via two electrodes. This stimulation
can alter neural excitability in the cortex and its effect can outlast
stimulation for up to one hour. Being a safe, cheap and mobile technique, this
makes tDCS a candidate for the clinical treatment of several neurological
disorders. However, more research needs to be performed in order to assess the
effects of tDCS inside the brain. We will use resting-state functional magnetic
resonance imaging (rs-fMRI) in order to investigate the effects tDCS exerts on
the functional connectivity networks in the brain.
Study objective
The objective of the study is to investigate the changes in cortical
connectivity patterns, as measured by resting-state fMRI, as a consequence of
the use of transcranial direct current stimulation.
Study design
Intervention study
Intervention
Transcranial direct current stimulation will be administered anodally over the
motor cortex with a current intensity of 1 mA and a duration of 15 minutes.
Study burden and risks
Transcranial direct current stimulation has been shown to be a very safe
technique with only minor adverse effects. During stimulation subjects will
probably experience a mild tingling sensation and possibly moderate fatigue or
a light itching sensation under the stimulation electrodes. After stimulation
there is a reasonable chance of transient headache and nausea. The total
experiment will only last one hour. There are no direct benefits for the
participants.
Postbus 9101
6500 HB Nijmegen
Nederland
Postbus 9101
6500 HB Nijmegen
Nederland
Listed location countries
Age
Inclusion criteria
Age: 18-65
Exclusion criteria
- any metal in body other than fillings or crowns
- cardiac arrhythmia
- claustrophobia
- pregnancy
- damaged skin at site of stimulation
- neuropsychiatric disorder or ongoing use of psychoactive medications
- history of neurological illness (including epilepsy) or neurosurgical procedure
- history of medication-resistant epilepsy in the family
- history of severe substance abuse
- previous treatment with tDCS
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL28989.091.09 |