The aim of this study is to compare (normal) histology to the images obtained by FCCM in marked sites.
ID
Source
Brief title
Condition
- Bronchial disorders (excl neoplasms)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The microscopic autofluorescence structure of normal and pathologic bronchial
mucosae will be analysed using real-time image reconstruction and video
mosaicing techniques. Pathology specimens will analyzed by a pathologist with
expertise in pulmonary disorders. Characteristics of images will be defined,
and related to the pathological findings.
Secondary outcome
NA
Background summary
Fibered confocal fluorescence microscopy is a new technique that produces
microscopic imaging of a living tissue through a 1-mm fiberoptic probe that can
be introduced into the working channel of the bronchoscope. The aim of the
present study is to correlate histology to the images obtained.
Study objective
The aim of this study is to compare (normal) histology to the images obtained
by FCCM in marked sites.
Study design
A descriptive study, in which confocal imaging will be recorded and bronchial
biopsies will be taken during the same bronchoscopy session in
well-characterized patients with an indication for surgery. During general
anesthesia, confocal imaging is performed at lobair carinae, first bronchial
generation, bronchiole, alveoli in three different segments. After imaging,
peripheral biopsy is taken and the surgery procedure will proceed. Markings of
biopsy site will be set using methylene blue dye.
Study burden and risks
The bronchoscopy will be performed, after the general anesthesia, by an
experienced pulmonologist. The studied extra investigation is confocal
microscopy with taking of biopsies, adding extra time (about 10 minutes) to the
procedure.
Meibergdreef 9
1105 AZ
Nederland
Meibergdreef 9
1105 AZ
Nederland
Listed location countries
Age
Inclusion criteria
Patients who undergo surgical procedure (lobectomy or pneumectomy)
Exclusion criteria
1. Only bullae on CT scan in lobectomy area
2. Severe interstitial lung disease
3. Patients who are pregnant
4. Previously radiotherapy on the surgery specimen.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL27181.018.09 |