To determine the impact of catheter ablation on the left atrium by visualizing scar tissue in the left atrium, using delayed enhancement MRI, and to correlate this to possible changes in left atrial size and function following catheter ablation.
ID
Source
Brief title
Condition
- Cardiac arrhythmias
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary study parameters are scar tissue in the left atrium and left atrial
size and function.
Secondary outcome
The secundary study parameters include age, gender, type of atrial
fibrillation, duration of atrial fibrillation, the presence of structural heart
disease and hypertension.
Background summary
Catheter ablation has proven to be an effective treatment of atrial
fibrillation. However, its impact on the left atrium is unknown. Scar tissue in
the left atrium, induced by the ablation procedure, may have an impact on left
atrial function which may have consequences for the medical treatment after
catheter ablation. If left atrial function is impaired after catheter ablation,
patients should receive anticoagulation in order to prevent thromboembolic
events.
Study objective
To determine the impact of catheter ablation on the left atrium by visualizing
scar tissue in the left atrium, using delayed enhancement MRI, and to correlate
this to possible changes in left atrial size and function following catheter
ablation.
Study design
This observational study will include patients with atrial fibrillation who
will be admitted for catheter ablation. Prior to and a few months after
catheter ablation, patients will undergo a cardiac MRI scan with additional
delayed enhancement imaging. After the conventional scan, patients will have to
wait for approximately 15 minutes while they are lying on the MRI table.
Afterwards, a second series of images will be obtained to depict scar tissue in
the left atrium which takes 5 minutes. Administration of an extra dose of
contrast agent will not be necessary. The obtained images will be used to
measure the extent of scar tissue in the left atrium before and after catheter
ablation and this will be correlated to the observed changes in left atrial
size and function. After catheter ablation, patients will be regularly seen at
the outpatient clinic to determine the rhythm status of the patients.
Participation in this study will have no further consequences regarding
treatment strategy or follow-up.
Study burden and risks
Participation in this study will not result in serious adverse events. Expected
minor adverse events may result from inconvenience due to a longer imaging
time, for example back pain or claustrophobia. Termination of the imaging
procedure will take place if these adverse events occur.
Heidelberglaan 100
3584 CX Utrecht
NL
Heidelberglaan 100
3584 CX Utrecht
NL
Listed location countries
Age
Inclusion criteria
- symptomatic, drug refractory AF
- age >= 18 years
- catheter ablation will be performed
- a minimum follow-up duration of 4 months
Exclusion criteria
- participation in another research
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL26887.041.09 |