The aim of this study is to compare the aerobic physical capacity of physically inactive CFS patients to relatively active patients and healthy controls.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
chronisch vermoeidheidssyndroom
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Maximal oxygen uptake, as achieved during a maximal exercise test
Secondary outcome
Percentage of patients achieving maximal exertion
Background summary
Patients with Chronic Fatigue Syndrome (CFS) often report an increase in
symptoms after physical exercise (Bazelmans et al. 2005). This may lead to
avoidance of physical activity, which will result in an even larger symptom
increase after physical exercise (Vercoulen et al. 1999). Several studies
reported that physical performance was diminished in CFS patients (Montague et
al. 1989, Riley et al. 1990, Sargent et al 1997, Sisto et al. 1996, Wallman
2004). This seems to be mainly due to the higher perceived effort, rather than
to reduced physical fitness (Sisto et al. 1996, Bazelmans et al. 2001, Wallman
et al. 2004). Unfortunately, the physical activity level of patients
participating in these studies was not taken into account. The model of reduced
activity, leading to reduced physical fitness, leading to symptom increase
might only be valid for physically inactive patients.
Study objective
The aim of this study is to compare the aerobic physical capacity of physically
inactive CFS patients to relatively active patients and healthy controls.
Study design
Case-control study
Study burden and risks
Only the maximal exercise test itself and lactate measurements are performed
especially for this study (1.5h).
Toernooiveld 214
6525 EC Nijmegen
Nederland
Toernooiveld 214
6525 EC Nijmegen
Nederland
Listed location countries
Age
Inclusion criteria
- female
- age between 18-50 years
- able to speak, read and write Dutch language ;additional criteria for patients:
- CDC criteria for CFS
- CIS fatigue score of 35 or higher, indicating severe fatigue
- Sickness Impact Profile score of 700 or higher
Exclusion criteria
- cardiac/pulmonary disease
- knee problems
- severe hypertension
- high fever within the last 6 weeks
- unable to undergo maximal exercise testing
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL26646.091.09 |