To determine the normal ferritin level in the anterior chamber, and to compare this with the ferritin level in HHCS patients.
ID
Source
Brief title
Condition
- Congenital and hereditary disorders NEC
- Anterior eye structural change, deposit and degeneration
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Aqueous and serum ferritin level.
Secondary outcome
NA
Background summary
In hereditary hyperferritinaemia-cataract syndrome (HHCS), ferritin production
is upgraded, with serum levels increasing to a tenfold of normal values,
without apparent disruption of the iron metabolism. The only relevant clinical
symptom is early-onset bilateral cataract due to crystalline ferritin
accumulating in the lens. It is unknown how this uptake occurs, and whether
this involves any active transport mechanism from, for instance, the anterior
chamber or not.
Study objective
To determine the normal ferritin level in the anterior chamber, and to compare
this with the ferritin level in HHCS patients.
Study design
Non-interventional, prospective, single-center study.
Study burden and risks
Participants do not benefit from this study. Risks are negligible.
Schiedamse Vest 180
3011 BH Rotterdam
Nederland
Schiedamse Vest 180
3011 BH Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
Age > 18 years.
Informed consent.
Scheduled for cataract surgery.
Exclusion criteria
HHCS.
Compromised iron metabolism (i.e. haemochromatosis).
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL28673.101.09 |