In this study, two central tenets of the Sensitization-Homeostasis Model (SHM) will be tested. The first tenet is that the liability of developing nicotine dependence derives from nicotine*s ability to stimulate neural pathways responsible for…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
middelengebruik (nicotine)
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
At each wave feelings of craving will be measured among adolescent smokers (or
ex-smokers) using previously validated indicators for latent craving,
cue-induced craving, current craving, and craving that comes on at a
predictable interval after the last cigarette.
Secondary outcome
At each measurement parental and peer smoking will be assessed.
Background summary
Among adolescent novice smokers, nicotine dependence can develop rapidly. Of
all dependence symptoms, craving is the most reported and the most prominent
barrier for smoking cessation. The occurrence and development of craving in
adolescent novice smokers has hardly been investigated. In research on
substance dependence, attention for the causative roles of gene-environment
interactions is increasing. The proposed study would be the first to identify
specific genetic and environmental mechanisms that underlie the emergence of
craving among novice smokers.
Study objective
In this study, two central tenets of the Sensitization-Homeostasis Model (SHM)
will be tested. The first tenet is that the liability of developing nicotine
dependence derives from nicotine*s ability to stimulate neural pathways
responsible for craving. In particular, activity in the dopaminergic system
appears to be associated with craving initiation. Variations in
dopamine-related genes can cause differences in dopaminergic functioning in the
brain, resulting in inter-individual differences in craving. The second tenet
of the SHM is that environmental cues, such as a seeing people smoke, can
increase craving for nicotine. Based on the notions of the SHM, this study aims
to elucidate the interaction between genetic influences and environmental
influences on the emergence and progression of craving among adolescent novice
smokers.
Study design
This study will have a six-wave longitudinal design. Self-report questionnaires
will be completed in which information on adolescents* own smoking behaviour
will be collected, as well as information on the exposure to smoking cues in
daily life, such as smoking of their parents and friends. At the first wave,
DNA samples will be collected by means of saliva and at each wave feelings of
craving will be assessed among (ex)smokers.
Study burden and risks
Because participants are only asked to fill out questionnaires and to provide a
small saliva sample only at the first wave, there is no risk and only a very
small burden.
Montessorilaan 3
6525 HR Nijmegen
NL
Montessorilaan 3
6525 HR Nijmegen
NL
Listed location countries
Age
Inclusion criteria
Adolescents in their first year of high school
Exclusion criteria
No elementary school children or high school students past their first year
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL27940.097.09 |