The aim of this study is to investigate if there are genetic factors predisposing to Löfgren*s syndrome, and whether these factors have an influence on the clinical course.
ID
Source
Brief title
Condition
- Immune disorders NEC
- Respiratory disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
To investigate an association between the genetics and the susceptibility to
Löfgren*s syndrome, DNA analysis will be done. For the genomic DNA extraction
whole blood will be used. When a genetic predisposition is found, in vitro
proliferation and cytokine production assays will be performed to investigate
the functional effects.
Secondary outcome
Our secondary objective is to investigate the blood analysis, pulmonary
function tests and radioscopic examination to distinguish between the patients
having a good and a bad prognosis. And to find parameters that could have
predicting value about the course and outcome of the disease.
Background summary
Löfgren*s syndrome is an acute and usually self-remitting phenotype of
sarcoidosis. Recent works indicate specific genetic background, infectious
transmission and exposure to environmental agents as main causes of
sarcoidosis. One could hypothesize that genetically predisposed hosts who are
exposed to certain environmental triggers are likely to develop the disease.
Study objective
The aim of this study is to investigate if there are genetic factors
predisposing to Löfgren*s syndrome, and whether these factors have an influence
on the clinical course.
Study design
An observational study
Study burden and risks
The patients will only come for one visit, and during this visit the anamnesis
will be taken, physical examination, pulmonary function test, radioscopic
examination and drawing blood will be done.
The risks of drawing blood from a vein are minimal.
Koekoekslaan 1/ postbus 2500
3430 EM Nieuwegein
NL
Koekoekslaan 1/ postbus 2500
3430 EM Nieuwegein
NL
Listed location countries
Age
Inclusion criteria
- Patients diagnosed with Löfgren*s syndrome.
- Löfgren*s syndrome is defined according to the latest ATS/ERS/WASOG statement as presenting the clinical features, i.e.:
o Acute symptoms like fever
o Bilateral hilar lymphadenopath on chest radiograph
o Erythema nodosum and/or joint symptoms (marked periarticular
inflammation or arthritis of the ankles)
- Capability of giving informed consent
Exclusion criteria
patients with:
- Non-Löfgren sarcoidosis
- Other granulomatous diseases
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL26386.100.08 |