To investigate the relation of platelet responsiveness and systemic platelet activity to phenotype in patients with severe hemophilia A.
ID
Source
Brief title
Condition
- Coagulopathies and bleeding diatheses (excl thrombocytopenic)
- Blood and lymphatic system disorders congenital
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
To investigate the association of platelet responsiveness (EC50 of CRP
stimulation, iloprost inhibition, and ADP stimulation) with clinical phenotype
in patients with severe hemophilia A.
Secondary outcome
To investigate the association of systemic platelet activation with clinical
phenotype in patients with severe hemophilia A.
Background summary
Large variability in phenotype has been observed in patients with severe
hemophilia A (<1% residual factor VIII activity), which indicates that
additional factors influence bleeding phenotype. This variability can not be
explained by levels of coagulation proteins. Platelet responsiveness and
systemic platelet activity might be these additional factors.
Study objective
To investigate the relation of platelet responsiveness and systemic platelet
activity to phenotype in patients with severe hemophilia A.
Study design
Platelet responsiveness to XL-CRP stimulation, Iloprost inhibition, and ADP
stimulation will be measured in freshly collected whole blood. Plasmamarkers of
platelet activity will be measured in plasma. The remaining material will be
saved (-80 degrees).
Study burden and risks
For this study an amount of 7.5 ml of blood will be drawn per patient at the
van Creveldkliniek. If possible this visit will be combined with a regular
visit to the van Creveldkliniek.
The results of this study will not be directly beneficial for the participating
patients. This study will improve to the knowledge about the role of blood
platelets in the variability in bleeding phenotype in hemophilia A.
Heidelberglaan 100
3584 CX Utrecht
NL
Heidelberglaan 100
3584 CX Utrecht
NL
Listed location countries
Age
Inclusion criteria
Severe hemophilia A
Most mild or most severe phenotype.
Age 18 years or older
Exclusion criteria
Alcohol abuse.
Use of medication which is known to influence platelet function
Drug use (cannabis).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL27236.041.09 |